丙型肝炎治疗药物研究与设计

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1、目录丙型肝炎治疗药物研究与设计………………………………………………………3以生命周期划分HCV治疗药物整理………………………………………4HCV的结构………………...……………………………………………4HCV生命周期………………………………………………………...…5以生命周期划分HCV治疗药物整理…………………………..............6总结和展望………………………...…………………………..……….13基于NS5A抑制剂的创新药物设计………………………………………14前言......

2、....................................................................................................14NS5A靶点...............................................................................................14NS5A抑制剂研究进展....................................

3、.......................................15BMS-790052(daclatasvir)研究................................................................20创新药物设计..........................................................................................24参考文献..................

4、................................................................................26TLR-7激动剂研究与设计………………………………………………….29目前已开发的激动剂..............................................................................29咪唑喹啉胺（imidazoquinolineamine）类.................

5、.................291-取代吡唑啉酮（1-SubstitutedPyrazolo(3,4-C)Ring）类......318-氧-去氮嘌呤类/咪唑并吡啶酮类............................................328-羟基腺嘌呤（8-Hydroxyadenine）类......................................36扩环8-羟基腺嘌呤类...........................................

6、.......................57艾沙托立宾（Isatoribine）衍生物类..........................................61BitriazolylAcyclonucleoside类...................................................64三氮唑类（Triazole）.................................................................6

7、5嘧啶类（Pyrimidine）.................................................................668-SubstituedBenzoazepines类....................................................68Aminodiazepine类.......................................................................69未

8、来可能的变动空间..............................................................................70创新药物设计..........................................................................................71参考文献..............................................