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1、IJCA-15956;NoofPages6InternationalJournalofCardiologyxxx(2013)xxx–xxxContentslistsavailableatSciVerseScienceDirectInternationalJournalofCardiologyjournalhomepage:www.elsevier.com/locate/ijcardCirculatingtransforminggrowthfactor-βasaprognosticbiomarkerinMarfansyndrome☆a,b,1a,b,1c
2、,1a,1a,b,1RomyFranken,AlexanderW.denHartog,ViviandeWaard,LeoEngele,TeodoraRadonic,d,1e,1f,1g,1ReneLutter,JannekeTimmermans,ArthurJ.Scholte,MaartenP.vandenBerg,h,1a,b,i,1a,b,⁎,1AeilkoH.Zwinderman,MaartenGroenink,BarbaraJ.M.MulderaDepartmentofCardiology,AcademicMedicalCenterAmster
3、dam,TheNetherlandsbInteruniversityCardiologyInstituteoftheNetherlands,TheNetherlandscDepartmentofMedicalBiochemistry,AcademicMedicalCenter,Amsterdam,TheNetherlandsdDepartmentofPulmonologyandExperimentalImmunology,AcademicMedicalCenter,Amsterdam,TheNetherlandseDepartmentofCardiol
4、ogy,St.RadboudUniversityMedicalCenter,Nijmegen,TheNetherlandsfDepartmentofCardiology,LeidenUniversityMedicalCenter,TheNetherlandsgDepartmentofCardiology,UniversityMedicalCenterGroningen,TheNetherlandshDepartmentofClinicalEpidemiologyandBiostatistics,AcademicMedicalCenter,Amsterd
5、am,TheNetherlandsiDepartmentofRadiology,AcademicMedicalCenter,Amsterdam,TheNetherlandsarticleinfoabstractArticlehistory:Background:PatientswithMarfansyndrome(MFS)areatriskforcardiovasculardisease.Marfanassociatedmuta-Received9November2012tionsintheFBN1geneleadtoincreasedtransfor
6、minggrowthfactor-β(TGF-β)activation.TheaimofthisstudywasReceivedinrevisedform15January2013toinvestigatetheroleofplasmaTGF-βasabiomarkerforprogressiveaorticrootdilatationanddissection.Accepted9March2013Methods:PlasmaTGF-βlevelandaorticrootdiameterbymeansofechocardiographywereasse
7、ssedin99MFSAvailableonlinexxxxpatients.After38monthsoffollow-upmeasurementoftheaorticrootwasrepeatedandindividualaorticrootgrowthcurveswereconstructed.Clinicaleventswereevaluated.TheprimarycompositeendpointwasdefinedasKeywords:aorticdissectionandprophylacticaorticrootreplacement.
8、MarfansyndromeTransforminggrowthfactorbeta(TGF-
