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1、抑郁症患者无抽搐电休克治疗的疗效与脑源性神经营养因子基因多态性抑郁症患者无抽搐电休克治疗的疗效与脑源性神经营养因子基因多态性【摘要】目的：探讨抑郁症患者脑源性神经营养因子(brain-derivedneurotrophicfactor,BDNF)基因两个单核甘酸多态性位点的多态性与无抽搐电休克治疗(modifiedelectroconvulsivetherapy,MECT)疗效的关系。方法：采用病例对照研究，研究组为110例符合美国精神障碍诊断统计手册第4版(DiagnosticandStatisticalManualofMentalDisorders,FourthEdi
2、tion,DSM-IV)抑郁症诊断标准的门诊及住院患者，对照组为100名正常人。患者入组后连续接受MECT8次，使用汉密顿抑郁量表(HamiltonDepressionRatingScaleforDepression,HRSD)进行抑郁严重程度及疗效评估。运用PCR扩增及测序的方法，分析BDNF基因rs6265、rs7103411单核昔酸多态性的分布,分析rs6265、rs7103411基因型及等位基因频率分布与MECT疗效的关系。结果：BDNF基因rs6265>rs7103411位点基因型及等位基因频率在对照组与患者组间的差异无统计学意义，MECT后2个位点基因型及rs
3、7103411等位基因频率在不同疗效组间的差异无统计学意义。rs6265位点A等位基因频率和G等位基因频率在减分率N50%组分别为47.9%、52.1%；在减分率<25%组分别为27.5%、72.5%,两组比较差异有统计学意义(P〈0.05),且A等位基因对MECT反应好于G等位基因(0R=1.740,95%CI：1.022^2.963)O结论：病情严重的抑郁症患者BDNF基因rs6265位点A等位基因可能与无抽搐电休克治疗效果有关，A等位基因携带者接受MECT的疗效较G等位基因携带者好。【关键词】抑郁症；脑源性神经营养因子；无抽搐电休克治疗;单核昔酸多态性；病例对照研究
4、中图分类号：R749.054,R749.41文献标识码：A文章编号：1000-6729(2011)002-0093-05doi:10.3969/j.issn.1000-6729.2011.02.省略[Abstract]Objective:Toexploretherelationofbrain-derivedneurotrophicfactor(BDNF)polymorphismswiththeresponsetomodifiedelectroconvulsivetherapy(MECT)inpatientswithmajordepressivedisorder(MDD).
5、Methods:Inthisstudy,110patientswithmajordepressionwereselectedaccordingtotheDiagnosticandStatisticalManualofMentalDisorders,FourthEditioncriteria,and100healthypersonwereusedascontrols.ThepatientsreceivedMECT8timesconsecutivelyandwereassessedwiththeHamiltonDepressionRatingScaleforDepressio
6、n(HRSD).Usingdirectsequencingafterpolymerasechainreaction(PCR),thesinglenucleotidepolymorphism(SNP)oftheBDNFgeners6265,rs7103411wereidentified.AndtheBDNFgeners6265,rs7103411genotypeandallelefrequencywerecounted.Results:NeitheroftheseBDNFpolymorphismshadsignificantdifferencesbetweentheheal
7、thycontrolsanddepressivepatients.AndthetwosinglenucleotidepolymorphismsiteswerenotassociatedwiththeresponsetoMECT.Inaddition,nosignificantdifferenceswerefoundinthegenotypesconcerningtheMECTresponseandalleleofrs7103411.However,thesignificantdifferencesintheAallelefre
