遗传学试题资料：群体遗传和线粒体.doc

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1、1.Panacinisahypotheticaldrugthatyouaretestinginalargepopulation.Youfindacontinuousdose-responsecurveinthepopulation.Ifyou’reinterestedinstudyinggeneticvariationthatcontributestopanacinresponse,whatdoesthissuggesttoyou?(9.0分)A.Onegenehasamajoreffectontheresponsetopanacin.B.Thenumberofgenesinvol

2、vedequalsthenumberofpeaksinthedose-responsecurve.C.Thereisathresholdofresponsecontrolledbyamajorgene.D.Therearelikelytobemultiplegenesinvolvedintheresponsetopanacin.E.Therearelikelytobemultiplegenesinvolvedintheresponsetopanacin.2.Wichofthefollowingbestexplainsvariableexpressioninmitochondrial

3、diseases?(9.0分)A.locusheterogeneityB.heterozygosityC.heteroplasmyD.modifierlociE.imprinting3.MarshaisheteroplasmicforaMELASmutation.WhatfeatureofoogenesismoststronglyinfluencesthelevelofmtDNAmutationshewillpasstoherchildren,whichwouldinfluencetheclinicalexpressionofdisease?(9.0分)A.Thesmallnumb

4、erofmitoticdivisionsduringoogenesisB.ThelongtimethatelapsesbetweenthebeginningandtheendofoogenesisC.Themitochondrialgeneticbottleneck线粒体遗传瓶颈D.EnergyrequirementsintheoocytethatinfluencenaturalselectionformtDNAmutationsE.ThelowfitnessofmtDNAmutationsintheoocyte4.Sometissuesareaffectedbymitochond

5、rialmutationsmoreseverelythanothers.Onewouldexpectthesetissueswouldhaveahighrequirementforwhichofthefollowing?(9.0分)A.ProteinB.MacromoleculartransportC.MetabolicenergyD.BloodflowE.Freeradicals5.RelativetonuclearDNA,themutationrateofmidochondrialDNAis:(9.0分)A.Apparentlylower,duetothenumberofcop

6、iesofmtDNApercellB.ApproximatelyequalC.Higher,duetolimitationsinDNArepaircapabilitiesD.Lower,duetoprotectionofthemitochondriafromenvironmentalinsults6.Sarahasmitochondrialencephalomyopathyandstroke-likeepisodes(MELAS).Hergeneticcounselortellsherthatitisverydifficulttopredicttheseverityofthesyn

7、dromeinanyaffectedchildrenthatshewillhave.Whatpropertyofmitochondrialmutations,whichisdistinctfromnuclearmutations,explainsthisvariabilityintheexpressionofmitochondrialmutations?(9.0分)A.mutationheteroplasmyB.incompletedominanceC.pleiotr