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时间:2020-09-15
《遗传学试题资料:群体遗传和线粒体.doc》由会员上传分享,免费在线阅读,更多相关内容在教育资源-天天文库。
1、1.Panacinisahypotheticaldrugthatyouaretestinginalargepopulation.Youfindacontinuousdose-responsecurveinthepopulation.Ifyou’reinterestedinstudyinggeneticvariationthatcontributestopanacinresponse,whatdoesthissuggesttoyou?(9.0分)A.Onegenehasamajoreffectontheresponsetopanacin.B.Thenumberofgenesinvol
2、vedequalsthenumberofpeaksinthedose-responsecurve.C.Thereisathresholdofresponsecontrolledbyamajorgene.D.Therearelikelytobemultiplegenesinvolvedintheresponsetopanacin.E.Therearelikelytobemultiplegenesinvolvedintheresponsetopanacin.2.Wichofthefollowingbestexplainsvariableexpressioninmitochondrial
3、diseases?(9.0分)A.locusheterogeneityB.heterozygosityC.heteroplasmyD.modifierlociE.imprinting3.MarshaisheteroplasmicforaMELASmutation.WhatfeatureofoogenesismoststronglyinfluencesthelevelofmtDNAmutationshewillpasstoherchildren,whichwouldinfluencetheclinicalexpressionofdisease?(9.0分)A.Thesmallnumb
4、erofmitoticdivisionsduringoogenesisB.ThelongtimethatelapsesbetweenthebeginningandtheendofoogenesisC.Themitochondrialgeneticbottleneck线粒体遗传瓶颈D.EnergyrequirementsintheoocytethatinfluencenaturalselectionformtDNAmutationsE.ThelowfitnessofmtDNAmutationsintheoocyte4.Sometissuesareaffectedbymitochond
5、rialmutationsmoreseverelythanothers.Onewouldexpectthesetissueswouldhaveahighrequirementforwhichofthefollowing?(9.0分)A.ProteinB.MacromoleculartransportC.MetabolicenergyD.BloodflowE.Freeradicals5.RelativetonuclearDNA,themutationrateofmidochondrialDNAis:(9.0分)A.Apparentlylower,duetothenumberofcop
6、iesofmtDNApercellB.ApproximatelyequalC.Higher,duetolimitationsinDNArepaircapabilitiesD.Lower,duetoprotectionofthemitochondriafromenvironmentalinsults6.Sarahasmitochondrialencephalomyopathyandstroke-likeepisodes(MELAS).Hergeneticcounselortellsherthatitisverydifficulttopredicttheseverityofthesyn
7、dromeinanyaffectedchildrenthatshewillhave.Whatpropertyofmitochondrialmutations,whichisdistinctfromnuclearmutations,explainsthisvariabilityintheexpressionofmitochondrialmutations?(9.0分)A.mutationheteroplasmyB.incompletedominanceC.pleiotr
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