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1、BaselStentCost-Effectiveness(BASKET)TrialBASKETTrialPresentedatTheEuropeanSocietyofCardiologyHotlineSession2005PresentedbyDr.MatthiasE.PfistererDrugElutingStentPrimaryEndpoint:Cost-effectivenessafter6months,witheffectivenessdefinedasreductionofmajoradver
2、secardiaceventsforthecomparisonofdrug-elutingstentvsbaremetalstent.BASKETTrialPresentedatESC2005BareMetalStent:VisionStentn=281826undergoingprimaryPCIirrespectiveofindicationforPCImeanfollow-up18months;6monthsreportedtodate,meanage64years,21%femaleConcom
3、itantmedications:clopidogrelfor6months(irrespectiveofstenttype),aspirinandstatintherapy19%Diabetic,27%priorMI,69%withtriplevesseldisease,52%LADlesions,26%txdwithglycoproteinIIb/IIainhibitorsTaxusStentn=281CypherStentn=264BASKETTrial:MACEat6MonthsPresente
4、datESC2005p=0.02p=0.62p=0.12p=0.08BASKETTrial:6MonthMACEMACEat6monthswaslowerintheDrug-ElutingStent(DES)groupcomparedwiththebaremetalstent(BMS)group.Thiswasprimarilyduetoareductionintargetvesselrevascularization(TVR)andlesssobyareductioninmyocardialinfar
5、ction,withnodifferenceincardiacdeath.ForthecomparisonofCypherandTaxusstents,therewerenosignificantdifferencesinMACEorcomponentsofMACEincludingTVR,MIorcardiacdeath(itshouldbenotedthatthetrialmaynothavebeenadequatelypoweredforthiscomparison)PresentedatESC2
6、005BASKETTrial:Cost-effectivenessPresentedatESC2005p<0.001p<0.001EurosBASKETTrial:Cost-effectivenessPresentedatESC2005InitialproceduralcostswerehigherwithDESthanBMS,resultinginhigheroverallcostduringtheindexhospitalization.Costsduringfollow-upwereslightl
7、ylowerintheDESgroup,althoughthisdifferencedidnotoffsettheinitialhigherindexhospitalizationcostsforDES,resultinginhighercoststhrough6monthsintheDESgroup.Thisresultedinacost-effectivenessratioof€18,031foroneMACEavoided,orthemorecommonlyusedcost-effectivene
8、ssratio,€54,546to€73,283peronequalitylifeyear(QALY)gained.Severalhigh-risksubgroupswereidentifiedthatpotentiallyhadabettercost-effectivenessratio,includingthoseaged>65years,triplevesseldisease,lesionlength>20mmandthosewith
