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1、BaselStentCost-Effectiveness(BASKET)TrialBASKETTrialPresentedatTheEuropeanSocietyofCardiologyHotlineSession2005PresentedbyDr.MatthiasE.PfistererDrugElutingStentPrimaryEndpoint:Cost-effectivenessafter6months,witheffectivenessdefinedasreductionofmajoradversecardiaceventsforthecompa
2、risonofdrug-elutingstentvsbaremetalstent.BASKETTrialPresentedatESC2005BareMetalStent:VisionStentn=281826undergoingprimaryPCIirrespectiveofindicationforPCImeanfollow-up18months;6monthsreportedtodate,meanage64years,21%femaleConcomitantmedications:clopidogrelfor6months(irrespectiveo
3、fstenttype),aspirinandstatintherapy19%Diabetic,27%priorMI,69%withtriplevesseldisease,52%LADlesions,26%txdwithglycoproteinIIb/IIainhibitorsTaxusStentn=281CypherStentn=264BASKETTrial:MACEat6MonthsPresentedatESC2005p=0.02p=0.62p=0.12p=0.08BASKETTrial:6MonthMACEMACEat6monthswasloweri
4、ntheDrug-ElutingStent(DES)groupcomparedwiththebaremetalstent(BMS)group.Thiswasprimarilyduetoareductionintargetvesselrevascularization(TVR)andlesssobyareductioninmyocardialinfarction,withnodifferenceincardiacdeath.ForthecomparisonofCypherandTaxusstents,therewerenosignificantdiffer
5、encesinMACEorcomponentsofMACEincludingTVR,MIorcardiacdeath(itshouldbenotedthatthetrialmaynothavebeenadequatelypoweredforthiscomparison)PresentedatESC2005BASKETTrial:Cost-effectivenessPresentedatESC2005p<0.001p<0.001EurosBASKETTrial:Cost-effectivenessPresentedatESC2005Initialproce
6、duralcostswerehigherwithDESthanBMS,resultinginhigheroverallcostduringtheindexhospitalization.Costsduringfollow-upwereslightlylowerintheDESgroup,althoughthisdifferencedidnotoffsettheinitialhigherindexhospitalizationcostsforDES,resultinginhighercoststhrough6monthsintheDESgroup.This
7、resultedinacost-effectivenessratioof€18,031foroneMACEavoided,orthemorecommonlyusedcost-effectivenessratio,€54,546to€73,283peronequalitylifeyear(QALY)gained.Severalhigh-risksubgroupswereidentifiedthatpotentiallyhadabettercost-effectivenessratio,includingthoseaged>65years,tripleves
8、seldisease,lesionlength>20mmandthosewith
