脱-γ-羧基凝血酶原及甲胎蛋白诊断原发性肝癌的临床价值.pdf

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1、中国当代医药2014年7月第21卷第l9期·医学检验·脱一一羧基凝血酶原及甲胎蛋白诊断原发性肝癌的临床价值石亚玲江笑文邝燕玲广州市第八人民医院检验科。广州510060【摘要】目的探讨脱～一羧基凝血酶原(DCP)及甲胎蛋白(AFP)诊断原发性肝癌的临床价值。方法选择原发性肝癌患者105例、慢性肝炎患者75例以及肝硬化患者39例为研究对象，分析DCP和AFP检测结果，并与病理金标准进行比较，评价两种方法对原发性肝癌诊断的灵敏度、特异度。结果DCP诊断原发性肝癌的灵敏度为80,95％，特异度为85．96％，与病理结果金标准的一致性好(Kappa=0．762)；AFP诊断原发性

2、肝癌的灵敏度为88。57％，特异度为91．23％，与病理结果金标准的一致性好(Kappa=O．824)；DCP和AFP联合检测诊断原发性肝癌的灵敏度为91．43％，特异度为96．49％；与病理结果金标准的一致性好(Kappa=0．883)。结论DCP和AFP联合检测能够显著提高原发性肝癌诊断的灵敏度、特异度以及与病理检测结果的一致性。【关键词1脱一^y一羧基凝血酶原；甲胎蛋白；原发性肝癌【中图分类号】R735．7【文献标识码】A【文章编号】1674—4721(2014)07(a)一0073—03ClinicalvalueofDCPandAFPinthediagnosis

3、ofprimaryhepaticcarci-nomaSillYa-lingJIAGNXiao-wenKUANGYan-lingDepartmentofLaboratory，theEighthPeopleSHospitalofGuangzhouCity，Guangzhou510060，China[Abstract]ObjectiveTodiscusstheclinicalvalueofdes-~／-carboxy-prothrombin(DCP)andalpha-fetoprotein(AFP)inthediagnosisofprimaryhepaticcarcinoma

4、．Methods105casesofpatientswithprimaryhepaticcarcinoma，75casesofpatientswithchronichepatitisand39casesofpatientswithlivercirrhosiswereselectedasresearchobjects．Testre—sultsofDCPandAFPwereanalyzedandcomparedwithpathologicalgoldstandard．Thesensitivity，specificityoftwomethodsindiagnosisofpri

5、maryhepaticcarcinomawereevaluated．ResultsSensitivityofDCPindiagnosisofprimaryhepaticcarcinomawas80．95％，specificityofDCPindiagnosisofprimaryhepaticcarcinomawas85．96％，withgoodconsistencyofpathologicalgoldstandard(Kappa=0．762)．SensitivityofAFPindiagnosisofprimaryhepaticcarcinomawas88．57％，sp

6、ecificityofAFPindiagnosisofprimaryhepaticcarcinomawas91．23％，withgoodconsistencyofpatho-logicalgoldstandard(Kappa=O．824)．SensitivityofDCPcombinedwithAFPindiagonisofprimaryhepaticcarcinomawas91．43％，specificityofDCPcombinedwithAFPindiagonisofprimaryhepaticcarcinomawas96．49％，withgoodconsiste

7、ncyofpathologicalgoldstandard(Kappa=0．883)．ConclusionDetectionofDCPcombinedwithAFPcansignifi-cantlyimprovethediagnosticsensitivityandspecificityofprimaryhepaticcarcinoma，aswellasconsistentwiththepathologicaltestresult．[Keywords]Des-~／-earboxy-prothrombin；Alpha-fetoprotein