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时间:2020-05-24
《钆塞酸二钠MR肝胆期对肝硬化背景下肝癌的诊断价值.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、中华医学杂志2014年2月25日第94卷第7期NatlMedJChina,February25,2014.Vo1.94,No.7.临床研究.钆塞酸二钠MR肝胆期对肝硬化背景下肝癌的诊断价值张涛陆健张学琴梁宏伟缪小芬姜吉锋丁丁杨雪飞【摘要】目的评估钆塞酸二钠(GD—EOB—DTPA)MR肝胆期对肝硬化背景肝癌的诊断价值。方法收集2011年10月至2012年12月,南通市第三人民医院43例肝硬化患者共45枚肝癌病灶,均行TWI、DWI、T,WI同反相位、GD—EOB—DTPA动态增强及肝胆期扫描。由2位阅片者分别对有、无肝胆期图像两种成像方法独立阅片。比
2、较阅片者诊断肝癌的信心评分、一致性、ROC曲线下面积、敏感性及阳性预测值。结果增加肝胆期图像:(1)两位阅片者诊断肝癌的信心评分均有增加,差异有统计学意义(P<0.05),且两位阅片者诊断肝癌的一致性提高;(2)两位阅片者诊断肝癌的ROC曲线下面积均有增加,但差异无统计学意义(P>0.05);(3)两位阅片者诊断肝癌的敏感性均有提高,差异有统计学意义(P<0.05),阳性预测值差异无统计学意义(P>0.05)。结论GD-EOB—DTPAMR肝胆期可提高阅片者对肝硬化背景肝癌的诊断信心及敏感性。【关键词】肝疾病;肝肿瘤;磁共振成像;钆DTPADiagn
3、osticvalueofhepatobiliaryphaseimagingwithGD·-EOB-DTPAforhepatocellularcarcinomasincirrhosisZhangTao,LuJiaa,ZhangXueqin,LiangHongwei,MiaoXiaofen,JiangJifeng,DingDing,地DepartmentofRadiology,ThirdMunicipalPeopleSHospital,Nantong226006,ChinaCorrespondingauthor:LuJian,Emai2:klfayzt@
4、socorn【Abstract】ObjectiveToassessthediagnosticvalueofhepatobiliaryphaseimagingwithGD—EOB—DTPAforhepatocellularcarcinomas(HCC)incirrhosis.MethodsAtotalof43cirrhoticpatientswith45HCClesionsunderwenttheexaminationsofT2WI,DWI,T1WIin—phaseandopposed—phaseanddynamiccontrastenhancemen
5、tandhepatobiliaryphase.Twoseparateanalysesofimagingsetwithandwithouthepatobiliaryphaseimageswereperformed.TheconfidencescoresforHCCdiagnosis,consistency,areaunderthereceiveroperatingcharacteristic(ROC)curveandsensitivityandpositivepredictivevaluesoftwoobserverswerecompared.Resu
6、ltsAfteraddinghepatobiliaryphase,therewasasignificantincreaseofconfidencescoresindiagnosingHCCbybothobservers(P<0.05)andtheconsistencyoftwoobserversalsoincreased.TheareaundertheROCcurveimprovedbybothobservers,butnosignificantdifferencesweredetected(P>0.05).Thesensitivityincreas
7、edsignificantly(P<0.05)andnosignificantdifferenceswereobservedforthepositivepredictivevaluesbybothobservers(P>0.05).ConclusionHepatobiliaryphaseimagingmayimprovethediagnosticconfidenceandsensitivityofGD—EOB—DTPAforHCCincirhosis.【Keywords】Liverdiseases;Liverneoplasms;Magneticres
8、onanceimaging;GadoliniumDTPA肝细胞肝癌(HCC)是我国最常见的恶性肿瘤诊断效能要
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