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1、肿瘤基础与临床2011年10月第24卷第5期∀397∀局部晚期宫颈癌术前新辅助化疗的应用价值赵晓东,吴为群,茅红艳,梁向华(启东市人民医院,江苏启东226200)摘要:目的评价新辅助化疗对于局部晚期宫颈癌的术前疗效和手术效果。方法新辅助化疗组32例局部晚期宫颈癌术前进行2个周期的TP方案化疗,化疗结束后2~3周行广泛全子宫切除加盆腔淋巴结清扫术,并以同期相同条件的直接手术的32例局部晚期宫颈癌作为对照,观察化疗前后肿瘤大小、SCC值的变化和化疗毒副反应,并对两组手术情况和术后病理进行比较分析。结果新辅助化疗组患者化疗后肿瘤明显缩小(P<0.05),其中
2、3例达到CR,20例达到PR,总有效率为71.88%;SCC值也明显下降(P<0.05);患者对化疗毒副反应均能耐受。与对照组相比,手术时间明显缩短,出血量明显减少,淋巴结阳性率、脉管受侵率及宫旁累及率显著降低(P<0.05)。结论局部晚期宫颈癌术前新辅助化疗安全有效,有利于肿瘤切除,可提高患者生活质量。关键词:局部晚期宫颈癌;新辅助化疗;手术中图分类号:R737.33;R730.53文献标识码:A文章编号:1673-5412(2011)05-0397-03TheApplicationValueofPreoperativeNeoadjuvantCh
3、emotherapyintheTreatmentofPatientswithLocallyAdvancedCervicalCancerZhaoXiaodong,WuWeiqun,MaoHongyan,LiangXianghua(QidongPeoplesHospital,Qidong226200,China)Abstract:ObjectiveToinvestigatethepreoperativeandoperativeeffectsofneoadjuvantchemotherapyinthetreatmentofpatientswithlocall
4、yadvancedcervicalcancer.MethodsTwocyclesofTPregimenchemotherapyweregiventothe32patientswithlocallyadvancedcervicalcancerbeforetheoperationintheneoadjuvantchemotherapygroup,thenradicalhysterectomyandpelviclymphadenectomyweregivenfor23weekslater.Theother32patientswiththesamecondit
5、ionreceivedprimarysurgeryasthecontrolgroup.Thetumorsize,thechangeofSCCandthechemotherapytoxicitieswereobservedbeforeandafterchemotherapy,andthesituationofoperationandthepostoperativepathologywerecomparedbetweenthetwogroups.ResultsThetumorsweresmallersignificantlyafterchemotherapy
6、intheneoadjuvantchemotherapygroup(P<0.05),amongthe32patients,the3casesgotCR,the20casesgotPR,thetotalresponseratewas71.88%;SCCdecreasedsignificantly(P<0.05);allthepatientscouldtoleratethechemotherapytoxicities.Comparedwiththecontrolgroup,theoperationtimewasshortenedsignificantly,th
7、eamountofbleedingwasreducedsignificantly,therateoflymphnodemetastasis,theinvasionrateofintravascularandtheinvolvementrateofparametriumdecreasedsignificantlyintheneoadjuvantchemotherapygroup(P<0.05).ConclusionPreoperativeneoadjuvantchemotherapyinthetreatmentoflocallyadvancedcervic
8、alcancerissafeandeffective
