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1、实习一：序列查询实验目的：1.了解三大生物信息中心的资源；2.学会用Entre系统查找目标序列；3.学会用SRS系统查找目标序列实验内容：（一）三大生物信息中心浏览NCBI、EBI、DDBJ（二）Entrez的使用LimitsandAdvancedSearch(三)SRS的使用作业：1.IntroducethefollowingNCBIdatabasesinyourownwords：MMDB，CDD，dbGap,PMC.，OMIM,UniGene,PubChem,RefSeq.1).MMDB:St
2、ructure(MolecularModelingDatabase)isThreedimensionalstructurewhichprovideawealthofinformationonthebiologicalfunctionandtheevolutionaryhistoryofmacromolecules.2).CDD:ConservedDomainDatabase(CDD)isaproteinannotationresourcethatconsistsofacollectionofwel
3、l-annotatedmultiplesequencealignmentmodelsforancientdomainsandfull-lengthproteins.3).dbGap:ThedatabaseofGenotypesandPhenotypes(dbGaP)isdevelopedtoarchiveanddistributetheresultsofstudiesthathaveinvestigatedtheinteractionofgenotypeandphenotype.4).PMC:Pu
4、bMedCentral(PMC)isafreearchiveofbiomedicalandlifesciencesjournalliteraturetokeepwithNLM’slegislativemandatetocollectandpreservethebiomedicalliterature.5).OMIM:OnlineMendelianInheritanceinMan(OMIM)isacomprehensive,authoritative,andtimelycompendiumofhum
5、angenesandgeneticphenotypes.6).UniGene:UniGeneisadatabasethatcomputationallyidentifiestranscriptsfromthesamelocus;analyzesexpressionbytissue,age,andhealthstatus;andreportsrelatedproteins(protEST)andcloneresources.7).Pubchem：PubChemisachemicalmoduledat
6、abasethatprovidesinformationonthebiologicalactivitiesofsmallmoleculeswhichincludessubstanceinformation, compoundstructures,andBioActivitydatainthreeprimarydatabases,Pcsubstance,Pccompound,andPCBioAssay,respectively8).RefSeq:TheReferenceSequence(RefSeq
7、)isacollectionwhichaimstoprovideacomprehensive,integrated,non-redundant,well-annotatedsetofsequences,includinggenomicDNA,transcripts,andproteins.2.MakealistofthemolecularbiologyrelatedbooksontheNCBIbookshelf,specifyingthebooktitle,authorsandpublishing
8、press.Howaboutbioinformaticsrelatedbooks?Molecularbiologybooks:1).MolecularBiologyoftheCell.4theditionAlbertsB,JohnsonA,LewisJ,etal..NewYork:GarlandScience;2002.2)LodishH,BerkA,ZipurskySL,etal.MolecularCellBiology.4thedition.NewYork:W.H.Freema
