胰泌素刺激-磁共振胰胆管成像定量分析猫慢性胰腺炎的胰腺外分泌功能.pdf

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1、·416·中国医学影像技术2012年第28卷第3期ChinJMedImagingTechnol，2012，Vol28，No3·◆◆实验研究Quantitativeanalysisofpancreaticexocrinefunctionofchronicpancreatitisincatmodelswithsecretin—stimulatedmagneticresonancech0langi0pancreat0graphyZHANGTing—ting。WANGLi，LYu—hua，HUANGZhi-jun。，LUJ

2、ian—ping。(1．DepartmentofRadiology，XinhuaHospital，ShanghaiJiaoTongUniversitySchoolofMedicine，Shanghai200092，China；2．DepartmentofRadiology，ChanghaiHospital，theSecondMilitaryMedicalUniversity，Shanghai200433；3．DepartmentofSurgery，theFirstPeople'sHospitalofYancheng

3、，Yancheng224005，China)EAbstract]ObjectiveToassessthevalueofsecretin—stimulatedmagneticresonancech。1angiopancreatography(S-MRCP)inauantitativeanalysisofpancreaticexocrinefunctioninchronicpancreatitis(CP)catmodels．MethodsThirty—twohealthyadultcatsweredividedinto

4、experimentalgroup(，z一24)andcontrolgroup(”一8)．Incompleteligationofpancreat—icductwasperformedoncatsinexperimentalgroupinordertoestablishCPmodels，whilecatsincontrolgroupreceivedashamoperation．S-MRCPwasperformedin3，5，and7weeksafterligationwith8catsexaminedateacht

5、imepointinex—perimentalgroup．CatsincontrolgroupunderwentpostoperativeS-MRCPimmediately．After,~MRCP，catsinexperimen—talgroupwereclassifiedintothreesubgroupsaccordingtothehistologicalanalysisofthepancreas：CP—I(slight)，CP1I(moderate)andCP—Ill(severe)．Increasingde

6、greesoffluidvolume(FVID)ingastrointestina1tractbeforeandafterinjec—tingsecretinwerestatisticallyanalyzed．ResultsFifteenCPmodelswereestablishedsuccessfullyinexperimentalgroup(n一24)，including7inCP—I，5inCP—IIand3inCP一1IIsubgroups．FVIDofexperimentalgroupwaslowerth

7、anthatofcontrolgroupat5and15minutesaftersecretininjection(F一9．742，13．543，bothP<0．05)．ThereweresignificantdifferencesofFVIDbetweencontrolgroupandCP一Ⅱsubgroup，aswellasbetweencontrolgroupandCP-1]Isubgroup(bothP％0．05)．Moreover，significantdifferenceofFVIDwasfoundbe

8、tweenCP—IandCP—Ilsubgroup(P0．05)，FVIDshowedadownwardtrendwithin—creasedworseningdegreesofCP．ConclusionS-MRCPc