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时间:2020-06-04
《胰泌素刺激-磁共振胰胆管成像定量分析猫慢性胰腺炎的胰腺外分泌功能.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、·416·中国医学影像技术2012年第28卷第3期ChinJMedImagingTechnol,2012,Vol28,No3·◆◆实验研究Quantitativeanalysisofpancreaticexocrinefunctionofchronicpancreatitisincatmodelswithsecretin—stimulatedmagneticresonancech0langi0pancreat0graphyZHANGTing—ting。WANGLi,LYu—hua,HUANGZhi-jun。,LUJ
2、ian—ping。(1.DepartmentofRadiology,XinhuaHospital,ShanghaiJiaoTongUniversitySchoolofMedicine,Shanghai200092,China;2.DepartmentofRadiology,ChanghaiHospital,theSecondMilitaryMedicalUniversity,Shanghai200433;3.DepartmentofSurgery,theFirstPeople'sHospitalofYancheng
3、,Yancheng224005,China)EAbstract]ObjectiveToassessthevalueofsecretin—stimulatedmagneticresonancech。1angiopancreatography(S-MRCP)inauantitativeanalysisofpancreaticexocrinefunctioninchronicpancreatitis(CP)catmodels.MethodsThirty—twohealthyadultcatsweredividedinto
4、experimentalgroup(,z一24)andcontrolgroup(”一8).Incompleteligationofpancreat—icductwasperformedoncatsinexperimentalgroupinordertoestablishCPmodels,whilecatsincontrolgroupreceivedashamoperation.S-MRCPwasperformedin3,5,and7weeksafterligationwith8catsexaminedateacht
5、imepointinex—perimentalgroup.CatsincontrolgroupunderwentpostoperativeS-MRCPimmediately.After,~MRCP,catsinexperimen—talgroupwereclassifiedintothreesubgroupsaccordingtothehistologicalanalysisofthepancreas:CP—I(slight),CP1I(moderate)andCP—Ill(severe).Increasingde
6、greesoffluidvolume(FVID)ingastrointestina1tractbeforeandafterinjec—tingsecretinwerestatisticallyanalyzed.ResultsFifteenCPmodelswereestablishedsuccessfullyinexperimentalgroup(n一24),including7inCP—I,5inCP—IIand3inCP一1IIsubgroups.FVIDofexperimentalgroupwaslowerth
7、anthatofcontrolgroupat5and15minutesaftersecretininjection(F一9.742,13.543,bothP<0.05).ThereweresignificantdifferencesofFVIDbetweencontrolgroupandCP一Ⅱsubgroup,aswellasbetweencontrolgroupandCP-1]Isubgroup(bothP%0.05).Moreover,significantdifferenceofFVIDwasfoundbe
8、tweenCP—IandCP—Ilsubgroup(P0.05),FVIDshowedadownwardtrendwithin—creasedworseningdegreesofCP.ConclusionS-MRCPc
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