首发抑郁症患者脑区低频振幅特征与症状群的相关性.pdf

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1、中华行为医学与脑科学杂志2014年8月第23卷第8期ChinJBehavMed＆BrainSci，August2014，Vo1．23，No．8·673··临床研究·首发抑郁症患者脑区低频振幅特征与症状群的相关性阎锐姚志剑汤浩韦茂彬陈建淮花玲玲卢青【摘要】目的探讨首发抑郁症患者脑局部神经元自发性活动能量特征与临床症状群的相关性。方法对22位首发抑郁患者和26位性别、年龄相匹配的健康对照，进行3．0T磁共振扫描。以受教育年限为协变量，比较两组受试脑区低频振幅(ALFF)值，将有统计学差异的脑区ALFF均值与临床症

2、状群严重程度进行相关分析。结果患者组较对照组右额中回(9，45，-6；K=18)和双侧梭状回(一34，一19，一12；K=37和30，一33，一18；K=31)ALFF值增高，左楔前叶(0，-72，42；K=19)ALFF降低(P0．05)。结论首发

3、抑郁症患者特定症状群的严重程度与静息状态下脑局部神经元活动强度异常有关。【关键词】抑郁症；静息态；低频振幅；临床症状．Amplitudeoflowfrequencyfluctuationinfirst-episodedepressionanditsrelationshipwiththeseparatesymptomclusters：aresting-statefMRIstudyleanRui，YaoZhOian，ngHao，WeiMaobin，ChenJianhuai，HuaLingling，LuQ．Depa

4、rtmentofPatientswithDepression，NanjingBrainHospitalAfiliatedtoNanfingMedicalUniversity，Nanjing210029，China【Abstract】0bjectiveToexploretherelationshipbetweenenergyfeatureofthespontaneousneuralactiv—ityandseparatesymptomclustersinfirst—episodedepression．Metho

5、ds22first—episodedepressionpatientsand26age-．gender—matchedhealthycontrolswerescannedwith3．0TMRIScanner．Thet—testwasemployedtocom—parethedifferenceofamplitudeoflowfrequencyfluctuation(ALFF)betweenthetwogroups，andthecorrelationanalyseswereconductedbetweenALF

6、Fofbrainregionswithsignificantdifferenceandtheseverityofdepressivesymptomsclusters．ResultsComparedwithhealthygroup，thedepressiongroupshowedsignificantlyincreasedALFFintherightmiddlefrontalgyms(9，45，一6；K：18)andthebilateralfusiformgyms(一34，一19，一12；K：37and30，一

7、33，一18；K=31，respectively)，anddecreasedALFFintheleftprecuneus(0，一72，42；K=19)(P<0．05，corectedbyAlphasim)．TheALFFofthethefightmiddlefrontalgyms，thefightfusiformgyms，andtheleftprecu—neuswerenegativecorelatedwiththescoresofweightfactor，retardationfactorandsleepd

8、isturbancefactor(r一0．494，P=0．019；r=一0．486，尸=0．022andr=一0．484，P=0．023，respectively)．ConclusionAbnormalenergyfeatureofthespontaneousneuralactivitymaybeassociatedwithseverityofspecificdepressivesymptomscl