静息态功能磁共振成像低频振幅评价无灶性癫痫患者脑功能.pdf

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1、·133O·中国医学影像技术2014年第3o卷第9期ChinJMedImagingTeehnol，2014，Vol30，No9◆：◆中枢神经影像学Amplitudeoflowfrequencyflucturationonresting-statefunctionalmagneticresonanceimagingevaluationofbrainfunctionsofnonlesionalepilepsypatientsLIAODa—wei，ZHANGTi-jiang，JIANGLin，WANGYa—nan，ZHANGGu

2、o—ming，LIUHeng，ZHUKe—we1"l，PENGLan(1．DepartmentofRadiology，AffiliatedHospitalofZunyiMedicalCollege，Zunyi563003，China；2．DepartmentofRadiology，theAffiliatedHospitalofLuzhouMedicalCollege，Luzhou646000，China)[-Abstract]0bjectiveToexplorethevalueofcerebralfunctionchang

3、esofpatientswithnonlesionalepilepsy(NLE)byamplitudeoflowfrequencyfluctuation(ALFF)techniqueonrestingstatefunctionalMRI(rs—fMRI)．MethodsForty-threepatients(NLEgroup)and46sex-，age-，educationlevel—andhandedness—matchedhealthyvolunteers(controlgroup)wereenrolled，whoun

4、derwentrs—fMRIby3．0TMRscanner．TheALFFwasanalyzedandcomparedbytwo-samplePtest．ThecorrelationsofALFFwithillnessdurationwereanalyzedinNIEgroup．ResultsComparedwithcontrolgroup，NLEpatientspresentedasincreasedALFFintheleftcerebellumposteriorlobe，righthippocampus，rightmi

5、ddlefrontalgyrus，rightsuperiortemporalgyrus，rightsuperiorfrontalgyrus，reducedALFFinrightprecuneus．Positivecorrelationswasfoundinthelefttemporallobesub—gyral，rightprecuneus，rightclaustrum，rightsuperiortemporalgyrusandleftpostcen—tralgyrusbetweenALFFandillnessdurati

6、oninNLEpatients，whilenegativecorrelationsintheleftinsula，leftprecentralgyrusandrightmiddlefrontalgyra1．ConclusionALFFcannon-invasivelydetecttherestingstatecerebralfunctionalchan—gesofNLEpatients．Understandingthecorrelationwithillnessdurationcanprovideatheoreticalb

7、asisforpathophysiologi—calmechanismofepilepsy．[-Keywords]Epilepsy；Magneticresonanceimaging；Amplitudeoflowfrequencyfluctuation静息态功能磁共振成像低频振幅评价无灶性癫痫患者脑功能廖大伟，张体江H，江林，王亚男，张国明，刘衡，朱克文，彭岚(1．遵义医学院附属医院影像科，贵州遵义563003；2．泸州医学院附属医院放射科，四川泸州646000)[摘要]目的探讨应用静息态功能磁共振成像(rs-fMRI)低频

8、振幅(ALFF)方法评价无灶性癫痫(NLE)患者脑功能改变的价值。方法对43例NLE患者(病例组)和46名性别、年龄、教育程度及利手与之相匹配的健康志愿者(对照组)，采用3．0T超导MR扫描仪进行静息态功能MR序列扫描，然后将病例组与对照组分别进行ALFF分析，再对AIFF分析结果进行两样本t检验，并分