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《葡萄球菌烫伤样皮肤综合征177例临床分析.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、中华皮肤科杂志2012年6月第45卷第6期ChinJDem1atol。June2012.Vo1.45.No.6431葡萄球菌烫伤样皮肤综合征177例临床分析李明勇魏光辉邱林傅跃先田晓菲吴清华【摘要】目的探讨177例葡萄球菌烫伤样皮肤综合征(ssss)患儿的诊断和治疗。方法回顾性研究177例SSSS患儿的临床资料。探讨其年龄和地区分布、发病诱因、临床特征、详细的实验室检查、病原菌分离培养和药敏、治疗方法以及预后情况。结果本组共177例,发病年龄中位数约为1岁3个月23天,多见于婴幼儿期,男女性别比约为8:9,71.2%于夏秋季节患病。患儿
2、多来自农村,148例(83.6%)无明确的发病诱因,多起病于颜面部(71.6%)。129例检查心肌酶谱104例(80.6%)异常,142例中38.7%分离出金黄色葡萄球菌。对近3年金黄色葡萄球菌药敏试验结果分析显示,头孢菌素类和阿莫西林/棒酸的敏感率分别为95.2%和95.0%。72.9%双联抗生素治疗有效,36.2%患儿早期予以丙种球蛋白,对于心肌酶异常患儿早期给予保护心肌药物,所有患儿痊愈且不留瘢痕。结论对于出现颜面部的急性红斑和表皮脱屑的婴幼儿应高度怀疑为SSSS,且予以及时的抗生素治疗,头孢菌素类和半合成青霉素复合制剂应是首选有
3、效的药物,同时早期合用丙种球蛋白和保护心肌药物有利于疾病恢复。Clinicalanalysisof177casesofstaphylococcalscaldedskinsyndromeL/Ming-yong,砌Guang-hui,QxuLin,FuYue-xian,"AⅣXiao-~ei,WUQing-hua.AffiliatedChildren%HospitdofChongqingMedicalUniversi@,KeyLaboratoryofDevelopmentalDiseasesinChildhoodofChongqingMed
4、icalUniversityandEducationMinistry,KeyLaboratory0fPediatricsinChongqing,ChongqingInternationalScienceandTechnologyCooperationCenterforChdDevelopmentandDisorders,Chongqing400014,ChinaCorrespondingauthors:WElGuang-hui,Email:ghwei@cqmu.edu.cn;QmLin,Emafl:qiulin118@126.corn【
5、Abstract】ObjectiveToassessthediagnosisandtreatmentofstaphylococcalscaldedskinsyndrome(SSSS)inchildren.MethodsAtotalof177childrenwithSSSSwereeligibleforthisstudy.Clinicaldatawereretrospectivelyreviewedtoassessthepatientsageandgeographicalareas,predisposingfactors,prodrome
6、,clinicalfeatures,resultsoflaboratoryexamination(includingbacterialisolationanddrugsusceptibilitytest)。treatmentandprognosis.ResultsThemedianageatonsetwas23dayspast15months.Infantsaged1t03yearswerethemostcommonlyaffectedpopulation.Themaletofemaleratiowas8:9.SSSSoccurredi
7、nsummerorautumnin71.2%ofthepatients.Mostpatientscamefromcountryside.Ofthesepatients.148(83.6%)hadnodefiniteinducement.13(7.3%)hadfeverorcoldhistorybeforetheoccurrenceofSSSS.Skinlesionsoftenbeganintheface(71.6%).Almostal1casespresentedwitherythemaandblisters.Abnormalmyoca
8、rdialenzymeswereobservedin104(80.6%)of129patients。andStaphylOCOCCUSaureLtswasisolatedfrom38.7%of142pati
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