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1、约物性肝病71例临床分析作者：丁秋玲，朴熙堵单位：延边大学附属医院消化内科，吉林延吉【摘要】［背景］探讨药物性肝病的病因及临床特点.［病例报告］采用同顾性分析方法对71例药物性肝病住院患者的用药史、临床表现、实验室检查结果及治疗效果进行调查分析.结果表明引起71例药物性肝病的相关药物中中药为17例(23.9%),抗结核类药物为16例(22.5%),抗生素类药物为13例(18.3%),抗肿瘤药物为9例(12.7%),解热镇痛药物为7例(9.9%),抗甲状腺类药物为4例(5.7%),中枢神经系统药物为2例(2.8%),其他为3例(4.2%).药物性肝病临床表现多样，无特异性.临床分
2、型以胆汁淤积型最常见，为30例(42.3%),其次为肝细胞型，为28例(39.4%),其他为混合型，为13例(18.3%).经停用致肝损伤药物及给予保肝等治疗，70例(98.6%)预后国好，1例(1.4%)发展为肝硬化.［讨论］药物性肝病多山中药、抗结核药及抗生素类药物引起，主要类型为胆汁淤积型，其次为肝细胞型;大多数药物性肝病预后良好，少数病例可发展为重症肝炎或肝硬化.【关键词】肝炎，慢性，药物性;胆汁淤积;预后Clinicalanalysisof71caseswithdruginducedliverdiseaseDINGQiuling,PIAOXixu*,LIChengha
3、o,JINYongri,JINAihua(DepartmentofGastroenterology,AffiliatedHospitalofYanbianUniversity,Yanji133000,Jilin,China)ABSTRACT:BACKGROUNDToinvestigatetheetiologicalfactorsandclinicalcharacteristicsofpatientswithdruginducedliverdisease.CASEREPORTSThemedicationhistory,clinicalmanifestation,laborator
4、yexamination,andtherapeuticeffectswereretrospectivelyanalyzedin71casesofdruginducedliverdisease.Therewerethe17cases(23.9%)oftraditionalChinesemedicine,16cases(22.5%)ofantituberculous,13cases(18.3%)ofantibiotics,9cases(12.7%)ofantitumor,7cases(9.9%)ofantipyreticanalgesic,4cases(5.7%)ofantithy
5、roid,2cases(2.8%)ofcentralnervoussystemagentsand3cases(4.2%)oftheothersin71casesofdruginducedliverdisease.Theclinicalmanifestationofdruginducedliverdiseasewasmultiplicityandhadnoparticularity.Theclinicaltypesofdruginducedliverdiseaseincluded30cases(42.3%)ofcholestasis,28cases(39.4%)ofhepatic
6、cellsand13cases(I8.3%)ofmixedtype.Afterthemedicinesinducingliverdiseasewerestoppedtouseandadministratingthehepatoprotectionmedicine,70patients(98.6%)werecuredwithgoodprognosis,andonlyonepatient(1.4%)progressedtolivercirrhosis.DISCUSSIONMostofthetraditionalChinesemedicine,antituberculous,anti
7、biotics,antitumormedicinesareinducedthedruginducedliverdisease,anditsmaintypesarecholestasis,andmostofdruginducedliverdiseasehasagoodprognosisbutindividualpatientsdevelopserioushepatitisandcirrhosis.Keywords:hepatitis5chronic,druginduced;cholestasi
