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1、肿瘤标志物CEA、TSGF联合检测对胸腔积液鉴别诊断的意义［摘要］目的：探讨肿瘤标志物联合检测在良、恶性胸腔积液鉴别诊断中的临床意义。方法：采集有胸腔积液患者的血清和胸腔积液样木各165例，其中，恶性胸腔积液患者55例，良性胸腔积液患者110例，用化学发光法检测患者血清和胸腔积液CEA、TSGF的含量。结果：恶性胸腔积液组血清CEA、TSGF的阳性率分别为58.82%和54.29%,胸腔积液CEA、TSGF的阳性率分别为75.76%和70.67%；其中,肿瘤标志物CEA、TSGF血清及胸腔积液的阳性率明显高于良性胸腔积
2、液组，差异有高度统计学意义(P<0.01)；两组含量的检测也得出相似的结果。联合检测血清CEA、TSGF诊断恶性胸腔积液的敏感度为85.71%,特异度为97.80%«结论：肿瘤标志物CEA、TSGF联合检测，对胸腔积液的鉴别诊断有较好的临床价值。［关键词］胸腔积液；癌胚抗原；恶性肿瘤特异生长因了；肿瘤标志物［中图分类号］R730.4E文献标识码］A［文章编号］1673-7210(2009)03(c)-019-02SignificanceofcombinedassaysoftumormarkerCEAandTSGFfor
3、differentialdiagnosisofpleuraleffusionZHANGYanghual,ZHENGDingrong2,ZHOUWei2(1.XixiangInstituteforHealthInspectionandSupervisionofBao,anDistrict,ShenzhenCity,Shenzhen518102,China;2.XixiangPeople'sHospitalofBao'anDistrict,ShenzhenCity,Shenzhen518102,China)［Abstrac
4、t］Objective:Tostudytheclinicalsignificanceoftumormarkerscombinedassayinthedifferentialdiagnosisofpleuraleffusion.Methods:165serumandhydrothoraxsampleswerecollectedfrom165inpatientswithpleuraleffusion.Amongthem,55patientsweresufferedwithmalignantpleuraleffusion,a
5、nd110patientswithbenignpleuraleffusion.Theconcentrationofcareino-embryonicantigen(CEA),andtumorspecificgrowthfactor(TSGF)weredeterminedbychemiluminescenceassay.Results:Inmalignantpleuraleffusiongroup,thepositiveratesofserumCEAandTSGFwere58.82%and54.29%respective
6、ly,thepositiveratesofhydrothoraxCEAandTSGFwere75.76%and70.67%respectively.Amongthem,CEAandTSGFinmalignantgroupweresignificantlyhigherthanthoseinbenignpleuraleffusiongroup(P<0.01).Thecontentdetectionalsoshowedsimilarresults.ThesensitivityofcombinedassaywithserumT
7、SGFindiagnosingmalignantpleuraleffusionwas85.71%,withthespecificityof97^80%.Conclusion:TumormarkersofCEAandTSGFhavehighclinicalvaluesinthedifferentialdiagnosisofpleuraleffusion.ThecombinedassaywithTSGFisrecommended.［Keywords］Pleuraleffusion;CEA;TSGF;Tumormarker肿
8、瘤标志物主要是指肿瘤细胞分泌或脱落到体液或组织中的物质，或是溶主对体内新生物反应而产生并进入体液或组织中的物质，此物质在正常人中缺乏或含量极低，肿瘤标志物癌胚抗原(CEA)存在于胚胎胃肠黏膜上皮与一些恶性组织细胞表面，对各部位的肿瘤缺乏专一性［1］。恶性肿瘤特异生长因子(TSGF)是一种能用于恶性肿瘤普查和早期诊断的指标，在恶性肿
