血管紧张素-（1-7）及贝那普利对大鼠慢性心力衰竭后心肌重构及心功能的影响-论文.pdf

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1、论著·中国当代医药2014年10月第21卷第28期血管紧张素一(1-7)及贝那普利对大鼠慢性心力衰竭后心肌重构及心功能的影响黄瑛邓贵智南昌市第三医院心内科，南昌330009[摘要1目的探讨血管紧张素一(1_7)fAng一(1-7)】及贝那普利对大鼠慢性心力衰竭(CHF)后心肌重构及心功能的影响。方法制作CHF模型雄性SD大鼠45只，随机分CHF组、Ang一(1—7)治疗组、Ang一(1—7)及贝那普利联合治疗组，另设15只为正常对照组，给药4周后检测血流动力学及心功能参数，检测大鼠心脏左室重量、左室重量指数及左室截面直径。结果与正常对照组

2、比较，CHF组左室重量及左室重量指数、左室截面直径明显增大(尸<0．01)。左室收缩压及左室内压最大上升和下降速率下降(P<0．01)；与CHF组比较，Aug一(1—7)治疗组左室重量及左室重量指数、左室截面积直径减小(P

3、的作用更明显。【关键词】血管紧张素一(1-7)；慢性心力衰竭；心肌重构；血流动力学【中图分类号】R541。6【文献标识码】A【文章编号】1674—4721(2014)1O(a)一0014—03Influenceofangiotensin-(1—7)andbenazeprilonmyocardialremodelingandcardiacfunctionofratswithchronicheartfailureHUANGYingDENGGui-zhiDepartmentofInternalMedicine，theThirdHospitalo

4、fNanchangCity，Nanchang330009，China【Abstract]ObjectiveToinvestigatetheinfluenceofangiotensin一(1—7)【Ang一(I一7J】andbenazeprilonthemyocardialre—modelingandcardiacfunctionofratswithchronicheartfailure．MethodsChronicheartfailure(cHmodelof45maleSDratswasbuiltandtheratswererandoml

5、ydividedintotheCHFgroup，theAug-(1-7)treatmentgroupandtheAug-(1-7)andbenazeprilcombinationtreatmentgroup．And15normalratswereassignedtothecontrolgroup．After4weeksofadministration，thehemodynamicandcardiacfunctionparametersweredetectedandtheleftventricularweight，leftventricul

6、armassindexandleftventricularCROSS—sectionaldiameteroftheratsweredetected．ResultsComparedtothenormalcontrolgroup，theleftventficularweight，leftventricularmassindexandleftventricularcross-sectionaldiameteroftheCHFgroupincreasedsignificantly(P<0．01)andtheleftventricularsysto

7、licpressureandleftventricularpressuremaximumriseandfallratesdecreased(P<0．01)．ComparedtotheCHFgroup，theleftventricularweight，leftventficularmassindexandleftventrieularcross—sectionaldiameteroftheAng-(1—71treatmentgroupdecreasedsignificantly(P<0．01)andtheleftventricularsys

8、tolicpressureandleftventricularpressuremaximumriseandfhllratesincreased(P<0．01)．ComparedtotheAug