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时间:2020-05-15
《甲状腺自身抗体在白癜风诊治中的应用价值.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、·1166·国际检验医学杂志2009年12月第3O卷第12期IntJLabMed,IX~ember2009,Vo1.30,Nn12·论著·甲状腺自身抗体在白癜风诊治中的应用价值冯玉丽余文辉周小梅李伟雄陈萍叶秋华【摘要】目的研究甲状腺过氧化物酶抗体(ATA)和甲状腺球蛋白抗体(抗一Tg)在白癜风诊治中的应用价值。方法选择100例(男52例,女48例)白癜风患者和8o例健康人(男38例,女42例)为研究对象,排除甲状腺疾病、甲状腺手术及接受甲状腺药物治疗的患者。2组对象的性别和年龄相当。所有对象都接受问卷调
2、查,内容包括人口统计学资料,甲状腺疾病相关症状,皮肤表现和甲状腺功能检测结果。甲状腺功能检测项目包括促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(fT3)、游离甲状腺素(fT4)和ATA、抗一Tg。结果白癜风患者23例(23Vo)血清ATA升高,11例(11)血清抗一Tg升高;而对照组只有5例血清(6.3)ATA升高,3例(3.8)血清抗一Tg升高,病例组与对照组差异具有统计学意义(P<0.05)。病例组血清TSH水平为(1.59±1.25)U/I,对照组血清TSH水平为(1.14±1.08)u/i,差
3、异具有统计学意义(P4、6.62;R758.41文献标识码:A文章编号:16734130(2009)12l166O3ApplicablevalueofthyroidautoantibodiesinthediagnosisandtherapeuticeffectevaluationforpatienswithvitiligoFENGYu—li,YUWen—hui,ZHOUXiao—mei,ela1.DepartmentofClinicalLaborato—ry,ShenzhenHospitalofTraditionalChine5、seMedicine,Shenzhen518033,China[Abstract]ObjectiveToinvestigatetheapplicablevalueofthyroidperoxidaseantibody(ATA)andanti—thyroglobulinantibody(TgAb)inthediagnosisandtherapeuticeffectevaluationforpatientswithvitiligo.MethodsOnehundredcasesofvitiligo(52mal6、es,48females)andeightyhealthysub—jects(38males,42females)wereenrolledinthisstudy.Thepatientswhohadathyroiddisease,his—toryofthyroidsurgeryorthosereceivingthyroidmedicationswereexcludedfromthestudy.Thesub—jectswerematchedingenderandage.Theclinicaldataofth7、esesubjectswereinvestigatedbyaques—tionnaire,includingthedemographicdata,symptomsrelatedtothyroiddiseasesandthemanifestationofskinandthyroidexamination.ThyroidfunctiontestsincludedTSH,freeT3(fT3),freeT4(fT4)andATA,TgAbwereperformed.ResultsTherewerestatis8、ticaldifferencesinincreasedcases(rate)ofserumATAandTgAbbetweenvititigogroupandhealthycontrolgroup[23(23)vs5(6.3),11(11)vs3(3.8),respectively](P<0.05).ThedifferenceinserumlevelofTSH(U/1)wassig—nificant(1.59±1.25vs1.14±1.08,
4、6.62;R758.41文献标识码:A文章编号:16734130(2009)12l166O3ApplicablevalueofthyroidautoantibodiesinthediagnosisandtherapeuticeffectevaluationforpatienswithvitiligoFENGYu—li,YUWen—hui,ZHOUXiao—mei,ela1.DepartmentofClinicalLaborato—ry,ShenzhenHospitalofTraditionalChine
5、seMedicine,Shenzhen518033,China[Abstract]ObjectiveToinvestigatetheapplicablevalueofthyroidperoxidaseantibody(ATA)andanti—thyroglobulinantibody(TgAb)inthediagnosisandtherapeuticeffectevaluationforpatientswithvitiligo.MethodsOnehundredcasesofvitiligo(52mal
6、es,48females)andeightyhealthysub—jects(38males,42females)wereenrolledinthisstudy.Thepatientswhohadathyroiddisease,his—toryofthyroidsurgeryorthosereceivingthyroidmedicationswereexcludedfromthestudy.Thesub—jectswerematchedingenderandage.Theclinicaldataofth
7、esesubjectswereinvestigatedbyaques—tionnaire,includingthedemographicdata,symptomsrelatedtothyroiddiseasesandthemanifestationofskinandthyroidexamination.ThyroidfunctiontestsincludedTSH,freeT3(fT3),freeT4(fT4)andATA,TgAbwereperformed.ResultsTherewerestatis
8、ticaldifferencesinincreasedcases(rate)ofserumATAandTgAbbetweenvititigogroupandhealthycontrolgroup[23(23)vs5(6.3),11(11)vs3(3.8),respectively](P<0.05).ThedifferenceinserumlevelofTSH(U/1)wassig—nificant(1.59±1.25vs1.14±1.08,
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