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时间:2020-05-14
《抗环瓜氨酸肽抗体与类风湿因子联合检测对类风湿性关节炎诊断价值.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、2012年12月第5O卷第34期·检验与临床·抗环瓜氨酸肽抗体与类风湿因子联合检测对类风湿性关节炎诊断价值童丹红王永丽朱平z吴小乐,1.浙江省台州市博爱医院检验科,浙江台州318050;2.第四军医大学西京医院临床免疫科,陕西西安710032;3.温州医学院附属第一医院检验科,浙江温州325000I摘要】目的探讨抗环瓜氨酸肽抗体(anti—CCP)与类风湿因子(RF)联合检测对类风湿性关节炎的诊断价值。方法分析133例类风湿性关节炎患者、67例非类风湿性关节炎者的血清anti—CCP、RF检测结果,其中anti—CCP测定采用微粒子酶免分析法测定.RF测定采用免疫散
2、射比浊法测定。结果@anti—CCP单独检测诊断类风湿性关节炎的灵敏度、特异度、阳性预测值、阴性预测值、诊断准确度分别为80.5%、89.5%、93.9%、70.0%、83.5%。@RF单独检测诊断类风湿性关节炎的灵敏度、特异度、阳性预测值、阴性预测值、诊断准确度分别为78.9%、64.2%、81.4%、60.6%、74.O%。(~)anti—CCP与RF联合检测诊断类风湿性关节炎的灵敏度、特异度、阳性预测值、阴性预测值、诊断准确度分别为77.4%、98.5%、99.0%、68.8%、84.5%。结论Anti—CCP与RF联合检测可使类风湿性关节炎的诊断特异度得到有
3、效提高,有利于类风湿性关节炎的鉴别诊断。f关键词】抗环瓜氨酸肽抗体;类风湿因子;类风湿性关节炎【中图分类号】R593.22【文献标识码】B[文章编号】1673—9701(2012)34—0059—02Clinicalvalueofserumanti-cycliccitrullinatedpeptideantibodycombinedwithrheumatoidfactorinthediagnosisofrheumatoidarthritisTONGDanhonfWANGYonglilZHUP_LnWUXiaoyue31.DepartmentofClinicalLab
4、oratory,TaizhouHumanitarianHospitalinZhejingProvince,Taizhou318050,China;2.De—partmentofClinicalImmunology,XijingHospitaloftheFourthMilitaryMedicalUniversity,Xi’an710032,China;3.De—partmentofClinicalLaboratory,theFirstAfiliatedHospitalofWenzhouMedicalCollege,Wenzhou325000,China[Abstrac
5、t]ObjectiveToinvestigatetheclinicalvalueofserumanti-cycliccitrullinatedpeptideantibody(anti-CCP)combinedwithrheumatoidfactor(Rinthediagnosisofrheumatoidarthritis.MethodsTheanti-CCPandRFresultsof133casesofrheumatoidarthritisand67casesofnon-rheumatoidarthritiswereanalyzed,andanti-CCPwasm
6、easuredbymicroparticleenzymeimmunoassay,whileRFwasmeasuredbyimmunenephelometry.ResultsFordiagnosisofrheumatoidarthritis,an—ti-CCPhadasensitivityof80.5%,specificityof89.5%,positivepredictivevalue(PPV)of93.9%,negativepredictivevalue(NPV)of70.0%,andoverallaccuracyof83.5%,andRFhadasensitiv
7、ityof78.9%,specificityof64.2%,PPVof81.4%,NPVof60.6%,andoverallaccuracyof74.O%,andcombineddetectionofanti—CCPandRFhadasensitivityof77.4%,specificityof98.5%,PPVof99.O%,NPVof68.8%,andoverallaceuracyof84.5%.ConclusionCombinationofanti-CCPwithRFcanimprovethediagnosticspecificityforrheumat
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