抗HCV与血清HBV-M电化学发光检测结果相关性分析.pdf

《抗HCV与血清HBV-M电化学发光检测结果相关性分析.pdf》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。

1、国际检验医学杂志2011年4月第32@~g5；NIntJLabMe&April2011,Vo1．32,No．5·553·——·论著·抗HCV与血清HBV—M电化学发光检测结果相关性分析宋霖，顾剑(武汉大学人民医院检验科，湖北武汉430060)摘要：目的回顾性分析患者抗HCV与HBVM检出情况，探讨HCV与HBV感染之间的相互关系。方法使用电化学发光法(ECI)比较分析196例抗HCV阳性患者与32026例抗HCV阴性患者血清HBVM单项检出率和不同模式的检出率。结果抗HCV阳性组HBVM检出率为73

2、．47；抗HCV阳性组HBsAb单阳性模式检出率低于抗HCV阴性组(P％0．05)；而HBcAb单阳性模式、HBeAb和HBcAb双阳性模式、HBsAg和HBcAb双阳性模式检出率却高于抗HCV阴性组(P0．05)，而单项HBeAb和HBcAb阳性率却高于HCV抗体阴性组(P<0．05)。结论HCV与HBV共感染在人群中分布面较广，共感染后存在互相干扰抑制作用，主要表现为HBcAb

3、、HBeAb的产生，及对保护性HBsAb产生过程的干扰与抑制。关键词：电化学发光法(ECL)；丙型肝炎病毒抗体(抗HCV)；乙型肝炎病毒标志物(HBVM)DOI：l0．3969／J．issn．1673—4130．20¨．05．010文献标识码：A文章编号：1673—4l3O(2011)050553—02Correlationanalysisofanti。‘HCVandserumHBV。。MbyelectrochemiluminescenceSongLin，GuJian(DepartmentofCli

4、nicalLaboratory，RenminHospitalofWuhanUniversity，Wuhan430060)Abstract：ObjectiveThesituationofHBVMweredetectedthroughretrospectiveanalysisofpatientswithanti—HCVtoinves—tigatetherelationshipbetweenHCVandHBVco—infection．MethodsUsetheECImethodtoreplacetheEL

5、ISAmethod，comparariveanalysisof196casesofantiHCVpositiveserumand30，026casesofanti—HCVnegativeserumHBVinfectionanditsdetectionrateandHBVMindividualdetectionrateofdifferentmodes．Resultsanti—HCVpositivegroupwithHBVMdetectionrateof73．47；anti—HCVpositivegro

6、upandindividualHBVsurfaceantibodypositive(2+)modedetectionratewassignificantlylowerthantheanti—HCVantibodynegativegroup；HBVcoreantibodyalone(5+)mode，HBVeantibody，HBVcoreantibodypositive(4+5+)modeandtheHBVsurfaceantigen，coreantibodypositive(1+5+)modewas

7、significantlyhigherthanthedetectionrateofHCVantibodynegativegroup：antiHCVpositivegroupandindividualHBsAg，HBeAgandantiHBsdetectionrateofHCVantibodynegativegroupwithnosignificantdifference，whilethesingleanti—HBeandantiHBcpositiveratewasKgnificantlyhigher

8、thanHCVantibodynegativegroup．ConclusionHCVandHBVinfectioninthepopulationdistributionofoverlappingcoversmoreoverlapthereisinterferenceinhibitionafterinfection，mainlyfortheanti—HBc，antiHBeproduction，andtheProtectiveanti—HBsproductionproce