菊花总黄酮对去势导致干眼症雄兔泪腺细胞 Fas、FasL表达的影响.pdf

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1、IntEyeSci，Vo1．14，No．10，oct．2014www．ies．net．cnTel：029-8224517282210956Email：IJO．2000@163．com·实验论著·菊花总黄酮对去势导致干眼症雄兔泪腺细胞Fas、FasL表达的影响姚小磊，彭清华，陈启雷，唐勇华，钟茜基金项目：国家自然科学基金地区基金项目(No．81260550)；广Thedryeyemode1wasestablishedwithorchiectomyon西壮族自治区自然科学基金资助项目(No．groupC，DandE．R

2、abbitsingroupEweretreatedwith2012GXNSFBA053092)；广西壮族自治区卫生厅中医药科技专totaIflavonoidofchrysanthemum．RabbitsingroupD项基金资助项目(No．GZPT1221)weretreatedwithandrogenintramuscuIarinjection．作者单位：(530011)中国广西壮族自治区南宁市，广西中医药RabbitsinthegroupA，groupB，groupCwastreated大学附属瑞康医院眼科；(

3、410007)中国湖南省长沙市，湖南中withnormalsaliRe．Allrabbitsweredetectedwith医药大学第一附属医院中医眼科学重点学科SchirmersItestandtearbreak—uptime(BUT)．Fas，作者简介：姚小磊，男，毕业于湖南中医药大学，医学博士，讲FasLwerecheckedonimmunohistochemistry．师，主治医师，研究方向：中西医结合治疗眼表疾病、眼底病。·RESULTS：TheSchirmersItestvaluesofgrouPEwa

4、s通讯作者：姚小磊．yxlshh@126．consignificantlyhigherthanthatofgroupC(P<0．01)and收稿日期：2014—05—27修回日期：2014—08-22theBUTvalueofgroupEwassignificantlylongerthanthatofgroupC(尸<0．01)．ThequantityofpositiveEffectsoftotalflavonoidofchrysanthemumexpressionofFasinglanduIartubecelIa

5、ndacinarepithelialcellandapoptosiscellsofgroupEafteronFasandFaslexpressioninlacrimaltreatmentat1．3．5moweresignificantlyIowerthanthatglandcellsofmalecastratedrabbitswithofgroupC，cellpopulationofthepositiveexpressionofdryeyeFasLwasobviouslyhigherthanthatofgroupC

6、(P<0．01)．·CONCLUSION：ThemaincomponentofchrysanthemumisXiao—LeiYao，Qing—HuaPeng，Qi—LeiChen，flavonoid，whichcouldsignificantlyinhibithappeningofYong—HuaTang．QianZhongdryeyeinrabbitafterandrogenIeveIloweredandlacrimalglandapoptosisandkeepbasictearssecretoryvoIumea

7、ndtearfiImstabiIity．Foundationitems：LocalFoundationofNationalNaturalScience·KEYWORDS：castrate；dryeye；lacrimalgland；apoptosis；Foundation(No．81260550)；NaturalScienceFoundationofGuan~totalflavonoidofchrysanthemumZhuangAutonomousRe,on(№．2012G)(NSFBA053092)；Heal~De

8、partmentofPharmaceuticalTechnologySpecialFoundation，GuangxiZhuangAutonomousRegion(No．GZPT1221)Citation：YaoXL，PengQH，ChenQL，eta1．EffectsoftotalDepartmentofOphthalmology，RuikangHospi