肺硬化性血管瘤120例临床病理分析.pdf

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1、·174·临床与实验病理学杂志JClinExpPathol2015Feb；31(2)网络出版时间：2015—2—509：51网络出版地址：http：／／www．cnki．net／kcms／detail／34．1073．R．20150205．0951．014．html肺硬化性血管瘤120例临床病理分析刘加夫，候立坤，武春燕摘要：目的探讨肺硬化性血管瘤(pulmonarysclerosinghemangioma，PSH)的临床病理特征及免疫表型。方法收集120例PSH的临床病理资料，探讨其临床特点、组织学特征及免疫表型。结果PSH肿块与周围肺组织界限清楚，切面

2、多为灰棕色，常伴出血灶。镜下可见两种肿瘤细胞、四种组织结构，多以混合形式存在(92／120，76．67％)，并常发现泡沫样细胞灶性聚集及肥大细胞散在分布(83／120，69．17％)。免疫表型：表面立方细胞及间质多角形细胞

3、rrF一1、EMA阳性，表面细胞sP—A、CK、NapsinA阳性，间质细胞vimentin阳性。结论PSH大体表现及镜下典型的“两种细胞，四种结构”组织特点是诊断PSH的重要依据，泡沫样细胞灶性聚集及肥大细胞散在分布对PSH诊断及鉴别诊断有重要提示意义。关键词：肺肿瘤；硬化性血管瘤；术中冷冻；泡沫样细胞及肥大细胞中图分类号：R734．

4、2文献标志码：A文章编号：1001—7399(2015)02—0174—04doi：10．13315／j．cnki．cjcep．2015．02．014Pathologicalfeaturesofpulmonarysclerosinghemangioma：ananalysisof120casesinfrozensectiOilLIUJiafu．HOULi—kuU．WUChun-yan(DepartmentofPathology，FuzhouPulmonaryHospital，Fuzhou350008，China；DepartmentofPathology，S

5、hanghaiPulmonaryHospital，rongiiUniversitySchoolofMedicine，Shanghai200433，China)Abstract：PurposeToanalyzeretrospectivelytheclinicopahologicalcharacteristicsandimmuophenotypein120casesofpulmonaryselerosinghemangioma(PSH)．MethodsDataof120casesofPSHwerecollectedandreviewed，includinggr

6、ossfeaturesandfrozendiagnosis，histopath01ogica1features，morphologyinHEandimmunohistochemicalcharacteristicsoftumorcells．ResultsPSHpres—entsawell—circumscribedmasswithasenseofexpansionaftercutting，whichshowedasolid，greytotan—yellowsurf'acewithfoeiofhaemorrhage．Twokindsoftumorcellsa

7、ndfourtypicalpatternswithmixedforms，areoftenshownunderlightmicroscope(92／120，76．67％)．Focalaccumulationofhistocytesandscatteredmastcellswerenotedinsomecases(83／120，69．17％)．Bothsurface,：ellsandroundcellswereTTF·1andEMApositive．SurfaceceilsexpressedSP—A．CKandNapsinA．Roundcellsexpress

8、edvimentin．ConclusionGrossfeaturesandtypical“twocelltypes，fourpatterns”contributetoPSHdiagnosis．Meanwhile，foalaccumulationoffoamhistocytesandscatteredmastcellsshowacluetoPSHdiagnosisanddifferentiMdiagnosis．Keywords：lungneoplasms；pulmonarysclerosinghemangioma；ft'ozendiagnosis；foams

9、ampletissuecellandmastceils肺硬化性血管