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《补阳还五汤治疗脑卒中后抑郁的疗效和安全性系统评价.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、1142_-中国中医急症2015年7月第24卷第7期JETCM.Ju1.2015.Vo1.24.No.7·x0l-究报告·补阳还五汤治疗脑卒中后抑郁的疗效和安全性系统评价木周曾璇陈雪梅易健刘柏炎2△.(1.湖南省邵阳市中西医结合医院,湖南邵阳422000;2.湖南中医药大学,湖南长沙410007)中图分类号:R743.9文献标志码:A文章编号:1004—745X(2015)07—1142—03d0i:10.3969/j.issn.1004—745X.2015.07.005【摘要】目的系统评价补阳还五汤治疗脑卒中后抑郁的有效性和安全性。方法纳入以脑卒中后抑郁患者为研究对象,比较补阳还五汤与
2、西药治疗效果的随机对照试验,评价纳入研究的质量,并用RevMan5_3软件进行Meta分析。结果补阳还五汤治疗脑卒中后抑郁患者总体疗效优于西药治疗.其汇总OR=2.24.95%CI[1.19,4.18],差异有统计学意义(JP<0.05);在改善汉密顿抑郁量表评分方面,补阳还五汤的效果较西药没有差异,汇总MD=0.00,95%CI[一0.97,0.98];安全性方面,补阳还五汤治疗脑卒中后抑郁发生明显不良反应低于西药治疗OR=0.07,95%CI[0.01,0.58],差异有统计学意义(P<0.05)。结论补阳还五汤治疗脑卒中后抑郁在总体疗效和安全性方面显示出比西药治疗更加有效的倾向,尚
3、需更多高质量研究以增加证据的强度。【关键词】补阳还五汤脑卒中后抑郁系统评价循证医学TheSystematicReviewoftheEfectsandSaflyofBuyangHuanwuTangonPost-StrokeDepressionZHOUZengxuan,CHENXuemei,YI~I71Z2,eto1.1TheShaoyangHospitalofIntegratedTCM&WM.Hunan.Shaoyang422000,China;2HunanUniversityofChineseMedicine,Hunan,Changsha410007,China-【Abstract】Ob
4、jective:TosystematicallyevaluatetheeffectsandsafetyofBuyangHuanwuTangonpost—strokedepression.Methods:Patientswithpost—strokedepressionwereidentifiedastheresearchobject.RandomizedcontrolledtrialswereusedtocomparetheeffectsofBuyangHuanwuTangwiththatofwesterntherapeutic.Thee.valuationwasincludedinth
5、equalityofstudieswithMetaanalysisofRevMan5.3software.Results:TheoveralleficacyofBuyangHuanwuTangonpatientswithpost——strokedepressionwassuperiortowesternmedicinetreat.ment,withitssummaryOR=2.24,95%CI[1.19,4.18].Thedifferencewasstatisticallysignificant(P<0.05).BuyangHuanwuTanginimprovingtheHAMDscor
6、eshadthesameeficacyaswesternmedicinetreatment,with.itssummaryMD=0.00,95%CI[0.01,0.58].Forthesecurityaspects,adversereactionsofBuyangHuanwuTangonpost—strokedepressionweresignificantlylowerthanthatofwesternmedicine,withitssummaryOR=0.07,95%CI[0.01,0.581.Thediferencewasstatisticallysignificant(P<0.0
7、5).Conclusion:BuyangHuanwuTangismoreel'-fectivethanWesternmedicinewithatendencyintheoverallefficacyandsafety,butstillneedsmorehigh-qualityresearchtostrengthenthisevidence.【Keywords】BuyangHuanwuTang;Post—s~okedepression
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