吉西他滨联合奥沙利铂经肝动脉栓塞化疗治疗中晚期肝癌的临床疗效-论文.pdf

《吉西他滨联合奥沙利铂经肝动脉栓塞化疗治疗中晚期肝癌的临床疗效-论文.pdf》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。

1、中华实用诊断与治疗杂志2O14年5月第28卷第5期JournalofChinesePracticalDiagnosisandTherapy·509··论著·吉西他滨联合奥沙利铂经肝动脉栓塞化疗治疗中晚期肝癌的临床疗效李金燕，白星，任欣乐，朱兵(河南科技大学第三附属医院洛阳东方医院肿瘤血液科，河南洛阳471003)摘要：目的探讨吉西他滨联合奥沙利铂经肝动脉栓塞化疗(transcatheterarterialchemoembolization，TAcE)治疗中晚期肝癌的疗效。方法中晚期肝癌患者92例按治疗方法分为观察组和对照组

2、各46例，对照组给予常规TAcE治疗，观察组于30min内动脉灌注奥沙利铂85～100mg／m。+吉西他滨8001000mg／m后行超液化碘油栓塞，2组均21d为1个周期，2个周期后评定疗效，并比较2组治疗前及治疗1个周期后甲胎蛋白(alphafetalprotein，AFP)、癌胚抗原(carcino—embryonicantigen，CEA)水平。结果观察组总有效率(76．09)高于对照组(52．17)(P<0．05)；2组治疗后AFP、CEA水平均较治疗前降低，观察组较对照组降低明显(P<0．05)；2组治疗期间骨髓

3、抑制，消化道反应，肝、肾功能异常及神经毒性发生率比较差异均无统计学意义(P>0．05)。结论吉西他滨联合奥沙利铂经肝动脉化疗栓塞治疗中晚期肝癌疗效满意，不良反应轻。关键词：中晚期肝癌；吉西他滨；奥沙利铂；肝动脉化疗栓塞TherapeuticeffectofgemcitabineplusoxaliplatinusedintranscatheterarterialchemoembolizationonadvancedlivercancerLIJin-yan，BAIXing，RENXin—le，ZHUBing(Departmen

4、tofOncologyandHematology，LuoyangDongfangHospital，theThirdAffiliatedHospitalofHenanUniversityofScienceandTechnology，Luoyang471003，China)Abstract：ObjectiveToinvestigatethetherapeuticeffectofgemcitabineplusoxaliplatinusedintranscatheterarterialchemoembolization(TACE)

5、onadvanced1ivercancer．MethodsNinety—twopatientswithadvanced1ivercancerweredividedintoobservationgroupandcontrolgroupaccordingtothedifferenttreatmentmethods，with46patientsineachgroup．ControlgroupreceivedroutineTACEtherapy，andobservationgroupreceivedarterialperfusio

6、nofgemcitabine(85to100mg／m。)plusoxaliplatin(800to1000mg／m。)in30minutes，followedbyembolismofultra—fluidlipiodol，for21daysasonecycle．Thetherapeuticeffectwasevaluatedafter2cycles．Thelevelsofalphafetalprotein(AFP)andcarcino—embryonicantigen(CEA)werecomparedbeforeandon

7、ecycleaftertreatmentbetweentwogroups．ResultsTheeffectiveratewas76．09inobservationgroup，higherthanthatincontrolgroup(52．17)(P

8、erencesintheincidencesofbonemarrowdepression，digestivesystemreaction，hepaticandrenalabnormalitiesandneurotox1city(P>0．05)．ConclusionsGemcitabineplusoxal