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《慢性乙型肝炎中医证候与实验室指标的相关性研究-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、国际检验医学杂志2014年3月第35卷第5期IntJLabMed,March2014,Vo1.35,No.5·545··临床检验研究论著·慢性乙型肝炎中医证候与实验室指标的相关性研究李菲菲,王蕾,张玮。(上海中医药大学附属龙华医院:1.检验科;2.肝科,上海200032)摘要:目的探讨慢性乙型肝炎中医证候与实验室指标的相关性。方法将145例慢性乙型肝炎患者按中医辨证分为湿热中阻证、肝郁脾虚证、肝肾阴虚证、瘀血阻络证和脾肾阳虚证5种证候,观察各证候与实验室指标的相关性。结果研究发现湿热中阻证与肝郁脾虚证在5种证候中所占比例最高,分别为53.8和31.7;湿热中阻证的总胆红素(TBiI)、间接胆红
2、素(IBiI)阳性率分别为69.4和68.8,明显高于其他3组,差异有统计学意义(P<0.05);而肝肾阴虚证患者的总胆汁酸(TBA)、丙氨酸氨基转移酶(ALT)及乙肝e抗原(HBeAg)的阳性率明显高于其他3组。湿热中阻证患者HBV-DNA病毒栽量明显高于其他3组(HBV—DNA>10copies/mI),病毒复制最为活跃。结论慢性乙型肝炎的中医证候与实验室指标有一定的相关性,实验室指标对慢性乙型肝炎的辨证论治有着较为重要的临床意义。关键词:肝炎,乙型,慢性;证候;实验室技术和方法DOI:10.3969/j.issn.1673—4l3O.2O14.05.016文献标识码:A文章编号:1673
3、—4130(2014)05—0545—02StudyonrelationshipbetweenTCMsyndromesandlaboratoryindexesofchronichepatitisBLiFeii,WangLei,ZhangWei。(1.DepartmentofClinicalLaboratory;2.DepartmentofLiver,LonghuaHospital,ShanghaiUniversityofTraditionalChineseMedicine,Shanghai200032,China)Abstract:ObjectiveTodiscusstherelationsh
4、ipbetweentraditionalChinesemedicine(TCM)syndromesandthelaboratoryindexesinchronichepatitisB.MethodsAccordingtotheTCMsyndromedifferentiation,145casesofchronichepatitisBweredivid—edintothe5syndromes:thestagnationofdamp—heatinmiddlejiao,thestagnationofliver—QIanddeficiencyofthespleen,thespleen—kidneyYa
5、ngdeficiency,thecollateralsobstructionbybloodstasisandtheliver—kidneyYindeficiency.Thecorrelationbe—tweentheTCMsyndromesandthelaboratoryindexeswasobserved.ResultsTheresearchfoundthatthestagnationofdamp—heatinmiddle—-jiaoandthestagnationofliver——QIanddeficiencyofthespleenhadthehighestproportioninthef
6、ivekindsoftheCMsyn—-dromes,whichaccountedfor53.8and31.7,respectively;Thepositiveratesoftotalbile(TBil)andindirectbile(IBil)inthestagnationofdamp—heatinmiddlejiaowere69.4and68.8respectively,whichweresignificantlyhigherthanthoseinother3groups(P<0.05);However。thepositiveratesoftotalbileacid(TBA),alanin
7、eaminotransferase(ALT)andHBeAgintheliverkidneyYindeficiencywerehigherthanthoseinother3groups.TheHBV—DNAviralloadinthestagnationofdamp—heatinmiddle-jiaowassignificantlyhigherthanthatinother3groups(HBV-
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