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时间:2020-05-08
《抑木汤对肝脾不和型D—IBS患者T淋巴细胞亚群的影响-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、第32卷第5期中华中医药学刊V01.32No.52014年5月CHINESEARCHIVESOFTRADITIONALCHINESEMEDICINEMav2014DOI:10.13193/j.issn.1673-7717.2014.05.030抑木汤对肝脾不和型D—IBS患者T淋巴细胞亚群的影响刘铁龙,路越,姚秋园(辽宁中医药大学附属第三医院,辽宁沈阳110003)摘要:目的:观察抑木汤对肝脾不和型D—IBS患者T细胞亚群的变化。方法:治疗组患者使用抑木汤,1剂煎3袋,各150mL。每天分3次温服,日1剂。治疗3周为1疗程。间隔1周后,继服第2个疗程。对照组口服思
2、密达5mg,3次/d,餐后服用。两组同上法服两个疗程。同时,选取了20例肠息肉内镜下切除术后复查者作为健康对照组。在两次疗程结束后均对外周血T细胞CD;、CD;、CDs+亚群进行测定。判定疗效。结果:外周血CD;细胞无异常,抑木汤治疗组及思密达对照组与健康对照组比较,治疗前D—IBS患者CD4+水平显著降低,CD;水平显著升高,导致CD4/CDs+比值下降(P<0.05);经两个疗程的治疗后抑木汤治疗组及思密达治疗组CD4+水平均升高,CDs水平均下降,但与治疗前比较无明显差异,其中,CD8水平较健康对照组仍有明显差异(P<0.05)。结论:抑木汤治疗组有着与思密
3、达对照组相同的免疫改善作用,且改善幅度更为明显。抑木汤对D—IBS的治疗作用部分是通过调整IBS异常的细胞免疫功能,并最终纠正胃肠的异常节律来实现的。关键词:肝脾不和型D—IBS;抑木汤;中医药治疗中图分类号:R259文献标志码:B文章编号:1673—7717(2014)05—1053-02EfectofInhibitingWoodDecoctionbyDetectingT—-lymphocyteSubsetsofPatientswithDisharmonyBetweenLiverandSpleenD—·IBSLIUTielong,LUYue,YAOQiuyuan
4、(TheThirdAfiliatedHospitalofLiaoningUniversityofTraditionalChineseMedicine,Shenyangl10003,Liaoning,China)Abstract:Dctive:ToobservetheeffectofInhibitingWoodDecoctionbydetectingT—lymphocytesubsetsofthepatientswiththedisharmonybetweenliverandspleenD—IBS.Method:Thetreatmentgrouppatientsus
5、edInhibitingWoodDecoction.Adosehad3bags,150mLforeach.Tookthreetimesaday,totallyonedose.3weekswasonecourseoftreatment.Afterone—weekinterval,thesecondcoursewouldcontinue.ThecontrolgrouporallytookSmecta5mgthreetimesadayaftermeal,takingthemedicinefortwocourses.Meanwhile,20casesofintestina
6、lpolypendoscopicre—sectionpatientsafterreviewwereselectedashealthycontrols.ThepercentageofCD3+,CD4+,CDsTlymphocytesubsetsofperipheralbloodsampleswereanalyzedattheendofthetwocoursesandtodeterminethecurativeeffect.Results:TheperipheralbloodCD3+cellswasnotsignificantlydifferentfromthatof
7、thecontrols(P>0.05).Beforetreatment,theCD4+wassignificantlylowerthanthatofhealthycontrolsandtheCD;washigherthanthatofthehealthycontrols.AndCD4/CD8ratiointhepatientswasincreasedsignificantlythanthoseinhealthycontrols.Aftertwocoursesoftreatment,thetreatmentgroupgCD4wasincreasedandtheCD8
8、dropp
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