欢迎来到天天文库
浏览记录
ID:54375532
大小:649.86 KB
页数:5页
时间:2020-05-01
《不同全麻方法对舌癌根治术患者T淋巴细胞亚群的影响.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、856JournalofOralScienceResearch,Sep.2013,Vo1.29,No.9不同全麻方法对舌癌根治术患者T淋巴细胞亚群的影响张铁军朱飞刘可斌(武汉大学口腔医学院麻醉科湖北武汉430079)[摘要]目的:评价不同全麻方法对舌癌根治术患者外周血T淋巴细胞亚群的影响。方法:择期舌癌根治术患者45例,ASA分级I或Ⅱ级,根据全麻方法分为:T组(全凭静脉麻醉),C组(静吸复合麻醉),I组(吸人麻醉)。3组患者术后均行静脉自控镇痛,视觉模拟评分法评价患者疼痛程度。于麻醉诱导前30min(TO)、麻醉后1h(T1)、3h(T2)、5h(T3)、手术结束时(T4
2、)、手术结束后24h(T5)、48h(T6)、72h(T7)时采集外周静脉血,采用流式细胞仪测定外周血T淋巴细胞亚群(CD3、CD4、CD8)百分比,计算CD4/CD8比值。结果:3组患者一般情况、手术时间、出血量、术后VAS评分差异无统计学意义。与TO比较,3组患者Tl~5时CD3、CD4百分比、CD4/CD8。。比值显著降低,c组和I组患者T6时CD3、CD4百分比、CD4/CD8比值亦低于TO水平(P<0.05);C组在T2~3的CD4、CD4/CD8比值显著低于T组(P<0.05),且其在T4~5的CD4、CD4/CD8比值显著高于I组(P3、6的CD3、CD4、CD4/CD8。比值显著低于T组(P<0.05),各组患者T1~7的CD8。。百分比与TO相比,差异无统计学意义。结论:以异丙酚、瑞芬太尼为主的全凭静脉麻醉对舌癌根治术患者外周血T淋巴细胞亚群抑制程度低,有利于维持细胞免疫功能。[关键词]麻醉全身T淋巴细胞亚群舌癌[中图分类号]R739.8[文献标识码]A[文章编号]1671—7651(2013)O9一O856一O5EffectsofDifferentGeneralAnesthesiaMethodsonTLymphocyteSubsetsinPatientsUndergoingRadicalOperati4、onforTongueCancer.ZHANGTie-jun,ZHUFei,L九,Ke—bin.SchoolofStomatology,WuhanUniversity,Wuhan430079[Abstract]Objective:ToinvestigatetheeffectsofdifferentgeneralanesthesiamethodsoncirculatingTlympho—cytesubsetsinpatientsundergoingradicaloperationfortonguecancer.Methods:45ASAIorⅡpatientsundergoi5、ngelectiveradicaloperationfortonguecancerwererandomizedto3groups(n一15each):Tgroupreceivedtotalintra—venousanesthesia;Cgroupreceivedcombinedintravenous-inhalationalanesthesiaandIgroupreceivedinhalationalanesthesia.Visualanaloguescores(VAS)wereusedtoevaluatethedegreeofpostoperativepain.Perip6、heralvenousbloodsamplesweretakenat30minbefore(TO)and1h(T1),3h(T2)and5h(T3)afterinductionofanesthesia,theendofoperation(T4)andat24h(T5),48h(T6)and72h(T7)afteroperationfordeterminationoftheper—centagesofTlymphocytesubsets(CD3+,CD4+,CD8+,CD4+/CD8+)withflowcytometer.Results:ThepercentagesofCD37、+,CD4+,andCD4+/CD8+ratioweresignificantlydecreasedduringandafteroperationatT1—5andalsoatT6inCgroupandIgroup(P<0.05).ThepercentageofCD4+cellsandCD4+/CD8+ratioweresignificantlylowerduringanesthesiaatT2—3inCgroupthaninTgroup(P<0.05).ThepercentagesofCD3+,CD4+,andC
3、6的CD3、CD4、CD4/CD8。比值显著低于T组(P<0.05),各组患者T1~7的CD8。。百分比与TO相比,差异无统计学意义。结论:以异丙酚、瑞芬太尼为主的全凭静脉麻醉对舌癌根治术患者外周血T淋巴细胞亚群抑制程度低,有利于维持细胞免疫功能。[关键词]麻醉全身T淋巴细胞亚群舌癌[中图分类号]R739.8[文献标识码]A[文章编号]1671—7651(2013)O9一O856一O5EffectsofDifferentGeneralAnesthesiaMethodsonTLymphocyteSubsetsinPatientsUndergoingRadicalOperati
4、onforTongueCancer.ZHANGTie-jun,ZHUFei,L九,Ke—bin.SchoolofStomatology,WuhanUniversity,Wuhan430079[Abstract]Objective:ToinvestigatetheeffectsofdifferentgeneralanesthesiamethodsoncirculatingTlympho—cytesubsetsinpatientsundergoingradicaloperationfortonguecancer.Methods:45ASAIorⅡpatientsundergoi
5、ngelectiveradicaloperationfortonguecancerwererandomizedto3groups(n一15each):Tgroupreceivedtotalintra—venousanesthesia;Cgroupreceivedcombinedintravenous-inhalationalanesthesiaandIgroupreceivedinhalationalanesthesia.Visualanaloguescores(VAS)wereusedtoevaluatethedegreeofpostoperativepain.Perip
6、heralvenousbloodsamplesweretakenat30minbefore(TO)and1h(T1),3h(T2)and5h(T3)afterinductionofanesthesia,theendofoperation(T4)andat24h(T5),48h(T6)and72h(T7)afteroperationfordeterminationoftheper—centagesofTlymphocytesubsets(CD3+,CD4+,CD8+,CD4+/CD8+)withflowcytometer.Results:ThepercentagesofCD3
7、+,CD4+,andCD4+/CD8+ratioweresignificantlydecreasedduringandafteroperationatT1—5andalsoatT6inCgroupandIgroup(P<0.05).ThepercentageofCD4+cellsandCD4+/CD8+ratioweresignificantlylowerduringanesthesiaatT2—3inCgroupthaninTgroup(P<0.05).ThepercentagesofCD3+,CD4+,andC
此文档下载收益归作者所有