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时间:2020-05-08
《失代偿期肝硬化患者医院感染的危险因素探讨-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、中华医院感染学杂志2014年第24卷第1O期ChinJNosocomiolVo1.24No.102014·2497·doi:10.11816/cn.ni.2014—132476·论著·失代偿期肝硬化患者医院感染的危险因素探讨罗灵和,赵建民,夏亮,刘海燕,陈军贤(浙江省立同德医院消化科,浙江杭州310012)摘要:目的探讨失代偿期肝硬化患者医院感染的危险因素,以控制和预防感染的发生,改善患者预后。方法回顾性分析150例失代偿期肝硬化住院患者临床资料,总结医院感染相关危险因素,采用SPSS13.0软件进行数据分析,将患者年龄、性别、肝功能分级、血清白蛋白、
2、白细胞计数、有无侵人性操作史、有无抗病毒治疗、住院时间作为自变量,是否并发感染为因变量,进行单因素logistic回归分析。结果150例患者发生医院感染32例,感染率21.3,失代偿期肝硬化患者医院感染主要类型有呼吸道感染、自发性细菌性腹膜炎;细菌培养共分离病原菌24株,主要病原菌依次为大肠埃希菌、肺炎克雷伯菌、肺炎链球菌、白色假丝酵母菌;感染患者多有肝功能分级高、白细胞计数低、低蛋白血症、侵入性操作史、住院时间长、未进行彻底抗病毒治疗等危险因素;多因素回归分析显示,肝功能分级、抗病毒治疗、侵入性操作及住院时间是影响失代偿期肝硬化患者医院感染的独立危险
3、因素(P4、ofZhejiangProvince,Hangzhou,Zhiang310012,China)Abstract:OBJECTIVEToexploretheriskfactorsfornosocomialinfectionsinpatientswithdecompensatedcirrho—siss0astopreventtheinfectionsandimprovetheprognosisofpatients.METHODSTheclinicaldataof150hospi—talizedpatientswithdecompensatedcirrhos5、iswereretr0spectivelyanalyzed,thentherelatedriskfactorsfornoso—comialinfectionswereobserved,thedatawereanalyzedwiththeuseofSPSS13.0software,theage,gender,liverfunctiongrade,serumalbumin,whitebloodcellscounts,invasiveoperation,antiviraltherapy,andlengthofhos—pitalstayweresetasthe6、independentvariables,theincidenceofinfectionsasthevariable,andtheunivariatelogis—ticregressionanalysiswasperformed.RESULTSThenosocomialinfectionsoccurredin32of150patientswiththeinfectionrateof21.3.Thenosocomialinfectionsinthedecompensatedcirrhosispatientswerecharacterizedbythere7、spiratorytractinfectionsandthespontaneousbacterialperitonitis.Atotalof24strainsofpathogenshavebeenisolatedfromthebacterialculture,amongwhichtheEscherichiacoli,Klebsiellapneumoniae,Streptococcuspneumoniae,andCandidaalbicanswerethepredominantspecies.Theriskfactorsfortheinfectionsi8、ncludedthehighliverfunctiongrade,lowwhilebloodc
4、ofZhejiangProvince,Hangzhou,Zhiang310012,China)Abstract:OBJECTIVEToexploretheriskfactorsfornosocomialinfectionsinpatientswithdecompensatedcirrho—siss0astopreventtheinfectionsandimprovetheprognosisofpatients.METHODSTheclinicaldataof150hospi—talizedpatientswithdecompensatedcirrhos
5、iswereretr0spectivelyanalyzed,thentherelatedriskfactorsfornoso—comialinfectionswereobserved,thedatawereanalyzedwiththeuseofSPSS13.0software,theage,gender,liverfunctiongrade,serumalbumin,whitebloodcellscounts,invasiveoperation,antiviraltherapy,andlengthofhos—pitalstayweresetasthe
6、independentvariables,theincidenceofinfectionsasthevariable,andtheunivariatelogis—ticregressionanalysiswasperformed.RESULTSThenosocomialinfectionsoccurredin32of150patientswiththeinfectionrateof21.3.Thenosocomialinfectionsinthedecompensatedcirrhosispatientswerecharacterizedbythere
7、spiratorytractinfectionsandthespontaneousbacterialperitonitis.Atotalof24strainsofpathogenshavebeenisolatedfromthebacterialculture,amongwhichtheEscherichiacoli,Klebsiellapneumoniae,Streptococcuspneumoniae,andCandidaalbicanswerethepredominantspecies.Theriskfactorsfortheinfectionsi
8、ncludedthehighliverfunctiongrade,lowwhilebloodc
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