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《Tβ4对非酒精性脂肪肝患者肝脏功能的评估价值-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、·432·胃肠病学和肝病学杂志2014年4月第23卷第4ChinJGastroenterolHepatol,Apr2014,Vo1.23,No.4——doi:10.3969/j.issn.1006-5709.2014.04.021T对非酒精性脂肪肝患者肝脏功能的评估价值田媛,王玉冰,谭莉莉,王阳阳,程勇1.河北大学附属医院消化内科,河北保定071000;2.河北省第七人民医院骨科;3.河北大学附属医院贵宾病房【摘要】目的分析胸腺素134(Thymosint34,T134)对非酒精性脂肪肝(non—alcoholicfattyliverdisease,NAFLD)患者
2、肝脏功能的评估价值。方法选取河北大学附属医院2010年5月一2011年5月收治的83例NAFLD患者及同期80例健康门诊体检者,分别纳入NAFLD组及正常组,对两组受试者肝功能及血清TI34指标进行对比,并观察NAFLD组患者治疗后上述指标变化。结果NAFLD组TG、ALT、AST、GGT、FPG、ALB指标显著高于正常组,其ALP低于对照组,两组相比,差异有统计学意义(P<0.05);NAFLD组显效31例,有效35例,无效l7例;治疗前NAFLD患者T134浓度显著低于正常组(P<0.05),治疗后NAFLD患者T134浓度显著升高,观察组患者升高程度更为显著(
3、P<0.05)。结论T134可有效反映NAFLD患者的肝脏功能,T134浓度的上升提示其肝脏功能的改善,而T[34浓度的下降则显示其肝功能受损严重,在今后的治疗中,应注重T134浓度的检测,以指导预后的判断和治疗方案的选择。【关键词】胸腺素134;非酒精性脂肪肝;肝脏功能;评估中图分类号:R5755文献标识码:A文章编号:1006—5709(2014)04—0432—03收稿日期:2013-09—22AppraisalvalueofTonliverfunctionofnon—alcoholicfattyliverdiseaseTIANYuan,WANGYubing,
4、TANLili,WANGYangyang,CHENGYong1.DepartmentofGastr0enterology,AfiliatedHospitalofHebeiUniversity,Baoding071000;2.DepartmentofOrthopae—dics,No.7People’sHospitalofHebeiProvince;3.VIPWard,AfiliatedHospitalofHebeiUniversity,China【Abstract】ObjectiveToanalyzetheappraisalvalueofthymosinbeta4(T
5、I34)oilliverfunctionofnon—alcoholicfattyliverdisease(NAFLD).Methods83casesofNAFLDand80casesofout—patientsexaminedhealthypatientsfromMay.2010toMay.2011inAfiliatedHospitalofHebeiUniversitywereincludedintheNAFLDgroupandthenor—malgrouprespectively,twogroupsofsnbjeetswithliverfunctionandser
6、umTB4indicatorswerecompared,andthechangesofaboveindexesaftertreatmentintheNAFLDgroupwereobserved.ResultsIntheNAFLDgroup,TG,ALT,AST,GGT,ALBandFPGweresignificantlyhigherthanthoseinthenormalgroup,theALPwaslowerthanthatinthenormalgroup,therewassignificantdiferencebetweentwogroups(P<0.05);i
7、nNAFLDgroup,therewere31casesofexcellence,35easesofavailability,and17casesofinvalid;TI34wassignificantlylowerintheNAFLDgroupthanthatinthenormalgroupbeforetreatment(P<0.05);TI34wassignificantlyincreasedinbothgroupsaftertreat—ment,whichwasmoresignificantintheNAFLDgroup(P<0.05).Conclusio
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