非酒精性脂肪肝患者血清AFP水平及其应用价值.pdf

《非酒精性脂肪肝患者血清AFP水平及其应用价值.pdf》由会员上传分享，免费在线阅读，更多相关内容在应用文档-天天文库。

1、142LabeledImmunoassays＆ClinMed，Apr．2014，Vo1．21，No．2非酒精性脂肪肝患者血清AFP水平及其应用价值黄晶，李志平(保定市第三医院检验科，河北保定071000)摘要：目的检测非酒精性脂肪肝(NAFLD)患者血清AFP水平，并探讨其应用价值。方法对97例患者进行评估，患者通过做腹部超声诊断确定为脂肪肝，并分成3个组。无脂肪肝患者作为对照组。所有患者和对照组进行体格检查、肝功能检测、稳态模型法评估胰岛素抵抗指数(HOMA—IR)检测。结果体质指数、AST、ALT、血糖、HOMA—IR等在NAFLD

2、患者中高于对照组。TG、总胆固醇、LDL—C、HDL—C水平在NAFLD中高于对照组。AFP水平在NAFLD中比对照组显著升高(5．43±2．65IU／mLvs2．33±0．99IU／mL，P<0．05)。三级NAFLDAFP水平显著高于一级NAFLD(6．69±2．36IU／mLVS3．56±1．60IU／mL，P<0．05)和二级NAFLDAFP水平(6．69±2．36IU／mLVS4．27±1．79IU／mL，P<0．05)。另外，二级NAFLDAFP水平显著高于一级NAFLD(P<0．05)。A、AST与其无相关性。结论NAFL

3、D患者AFP水平高于非脂肪肝患者，AFP水平与脂肪病分级有关，NAFLD分级与血清AFP水平的相关性独立于其它因素。关键词：甲胎蛋白；肝脏；脂肪病变；非酒精性脂肪肝TheValueofAFPLevelElevationinNonalcoholicFattyLiverDiseaseHUANGJing，LIZhi—ping(Departmentoflaboratory，TheThirdHospitalofBaoding，Baoding071000，China)Abstract：ObjectiveToanalyzetheimportanceo

4、fAFPlevelinnonalcoholicfattyliverdisease(NAFLD)．MethodsDegreeofliversteatosisin97patientswasgradedintothreegroups．Asacontrolgroup，patientswithoutfattyliverorotherliverdiseaseswereincluded．Allpatientsandcontrolswerecarriedoutaphysicalexamination，biochemicalanalysesincludi

5、ngliverfunctiontests，thecomponentsofthemetabolicsyndrome，andthehomeostasismodelassessmenttoestimateinsulinresistance(HOMA-IR)scorewereperformed．ResultsBodymassindex，AST，ALT，glucose，insulinandHOMA—IRinpatientswithNAFLDwerehigherthanthatincontrolgroup．TheTG，TC，LDL—C，andHDL

6、—ClevelsinNAFLDgroupwerehigherthanthatincontro1．AstatisticallysignificantincreaseinAFPlevelswasnotedinpatientswithNAFLDwhencomparedwithcontrols(5．43±2．65IU／mLvs2．33±0．99IU／mL，P<0．05)．AstatisticallysignificantincreaseinAFPlevelswasnotedinpatientswithgrade3NAFLDwhencompare

7、dwithgrade1f6．69±2．36IU／mLvs3．56±1．60IU／mL，P<0．05)andgrade2NAFLDgroups(6．69IU／mL±2．36IU／mLvs4．27．4-1．79IU／mL，P<0．05)．AFPingrade2NAFLDgroupwassignificantlyhigherthanthatingrade1．AFPwascorrelatedwithNAFLDgrade．Accordingtomultivariateanalysis．thecorrelationbetweenNAFLDgrade

8、andserumAFPlevelswasindependentfactorstoNAFLD．ConclusionPatientswithNAFLDhavehigherAFPlevelsthanthosewi