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时间:2020-05-07
《S-腺苷蛋氨酸对梗阻性黄疸患者术后肝功能及营养状况影响的临床研究-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、现代生物医学进展www.shengwuyixue.comProgressinModernBiome~cmeVoL14NO.1JAN.2014·147·DOI:10.13241~.cnki.pmb.2014.01.036s.腺苷蛋氨酸对梗阻性黄疸患者术后肝功能及营养状况影响的临床研究齐敦峰李欢送姜新春△孟凡军张昕辉刘养岁(徐州中心医院肝胆胰外科江苏徐州221009)摘要目的:探讨s一腺苷蛋氨酸对梗阻性黄疸患者术后肝功能及营养状况的影响。方法:选择2010年8月至2012年7月我院肝胆病区收治的90例梗阻性黄疸患者为研究对象,随机分为s一腺苷蛋氨酸治疗组(48例)和对照组
2、(42例),比较和分析静脉滴注s一腺苷蛋氨酸对梗阻性黄疸患者术后第5d、10d肝功能及营养指标的影响。结果:术后5d、10d,两组患者血总胆红素、直接胆红素、谷丙转氨酶、^v.谷氨酰转肽酶、碱性磷酸酶水平较术前ld显著降低,且组内比较差异有统计学意义(P<0.05),治疗组以上指标的下降程度较对照组更明显,差异有统计学意义(P<0.05)。术后第10d,两组患者的血白蛋白、前白蛋白、转铁蛋白水平较术后第5d显著改善(P<0.05);术后第5、10d,两组组间血白蛋白、前白蛋白、转铁蛋白水平比较差异有统计学意义(P<0.05)。结论:梗阻性黄疸患者术后应用腺苷蛋氨酸能促
3、进黄疸消退,加快胆红素的排泄和肝功能的恢复,有利于患者营养状况的改善。关键词:梗阻性黄疸;s一腺苷蛋氨酸;肝功能;营养;术后中图分类号:R657.43文献标识码:A文章编号:1673—6273(2014)O1—147—03ObservationontheEfiectofS.adenosyl—L—methionineonPost—operativeLiveFunctionandNutritionalStatusinPatientswithObstructiveJaundiceQIDun-feng,LIHuan—song,JIANGXin—chun△.MENGFan-ju
4、n,ZHANGXin-huiL1UYang-sui(XuzhouCentralHospitalofHepatobiliaryspleensurgical,Xuzhou,Jiangsu,221009,ChinaJABSTRACTObjective:TostudytheefectsofS-adenosylmethionineonpost-operativeliverfunctionandnutritionalstatusinpatientswithobstructivejaundice.Methods:90casesofobstructivejaundiceadmitte
5、dfromAugust2010toJuly2012wereselectedanddividedintotheexperimentalgroup(withS-adenosylmethioninetreatment)andcontrolgrouprandomly.TheefectofintravenousinfusionwithS-adenosylmethionineontheliverfimctionandnutritionindicatorson5and10daysafteroperationinpatientswithobstructivejaundicewerec
6、omparedandanalyzed.Results:5and10dayspostoperation,theTBIL,DBIL,ALT,一GTandALPlevelsweresignificantlyreducedcomparedwiththosepre—operation(P<0.05),whichwereobviouslylowerintheexperimentalgroupcomparedwiththecontrolgroup(P<0.05).10daysafterpostoperation,thelevelsofAlb,PA,TFoftwogroupsboth
7、significantlyimprovedcomparedwiththoseafter5dayspostoperation(P<0.05);whichweresignificantlydiferentbetweenthetwogroups5and10daysafterpostoperation(P<0.05).Conclusion:S-adenosylmethioninecouldpromotetheexcretionofserumbilirubin,jaundicesubsidise,recoveryofliverfunctionaswellast
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