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时间:2020-05-07
《慢性 HBV 感染者不同免疫状态证候虚实分类与T、B及NK细胞亚群的相关性研究-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、重庆医学2014年2月第43卷第6期641·论著·慢性HBV感染者不同免疫状态证候虚实分类与T、B及NK细胞亚群的相关性研究张兵,杨丽莎,唐美媛。,张敏,聂琳(桂林医学院附属医院:1.消化内科;2.中医科;3.检验科,广西桂林541001)摘要:目的了解慢性乙型肝炎病毒(HBV)感染者不同免疫状态证候虚实分类与T、B细胞亚群及自然杀伤(NK)细胞之间的相互关系。方法将3种不同免疫状态的慢性HBV感染者分为虚证组、实证组,检测其外周血淋巴细胞亚群和NK细胞,并对上述各组指标进行比较分析。结果在3种不同免疫状态中,所有虚实两组患者的CD44。T细胞百分比均较对
2、照组(健康献血员)低(P3、伤细胞,天然;慢性乙型肝炎;免疫状态;中医证型分类doi:10.3969/J.issn.16718348.2014.06.001文献标识:鸥iA文章编号:1671-8348(2014)060641—03TheTCMsyndromeclassificationofdifferentimmunestatusofchronicHBVinfectionandT,BandNKcellssubgroupcorrelationstudiesZhangBing.YangLisha,TangMeiyuan。,ZhangMin,NieLin(1.DepartmentofGas4、troenterology;2.DepartmentofTraditional'ChineseMedicine;3.DepartmentofClinicalLaboratory,AffiliatedHospitalofGuilinMedicalCollege,Guilin,Guangxi541001,China)Abstract:ObjectiveToinvestigatethedifferentimmunestatusofTCMclassificationandthelevelsofTandBcellsandthere—lationshipbetween5、theNKcells.MethodsThreedifferentimmunestateofpatientswithchronicHBVweredividedintoastheniasyndrome(AS)groupandstheniasyndrome(SS)group,andthenwedetectedtheperipheralbloodlymphocytesubsetsandNKceIIs,andcomparedtheaboveeachindexanalysis.ResultsInthreedifferentimmunestatus,allpatient6、swithASandSSgroupsCD4Tcellpercentagesarelowerthannormalcontrolgroup(Pcontrolgroup>theASgroup(P7、ofCD4/CD8SSgroupweresignificantlylowerthantheASgrouporcontrolgroup,inastateofimmuneclearancetheSSandtheASgroupBlymphocytepercentagewerehigherthanthecontrolgroup.thepercentageofNKcellswaslowerthanthecontrolgroup(P<0.05).ConclusionChronicHBVinfectionhaveimmunedysfunction:HBVinfected8、differentimmunestatusofTCMclassif
3、伤细胞,天然;慢性乙型肝炎;免疫状态;中医证型分类doi:10.3969/J.issn.16718348.2014.06.001文献标识:鸥iA文章编号:1671-8348(2014)060641—03TheTCMsyndromeclassificationofdifferentimmunestatusofchronicHBVinfectionandT,BandNKcellssubgroupcorrelationstudiesZhangBing.YangLisha,TangMeiyuan。,ZhangMin,NieLin(1.DepartmentofGas
4、troenterology;2.DepartmentofTraditional'ChineseMedicine;3.DepartmentofClinicalLaboratory,AffiliatedHospitalofGuilinMedicalCollege,Guilin,Guangxi541001,China)Abstract:ObjectiveToinvestigatethedifferentimmunestatusofTCMclassificationandthelevelsofTandBcellsandthere—lationshipbetween
5、theNKcells.MethodsThreedifferentimmunestateofpatientswithchronicHBVweredividedintoastheniasyndrome(AS)groupandstheniasyndrome(SS)group,andthenwedetectedtheperipheralbloodlymphocytesubsetsandNKceIIs,andcomparedtheaboveeachindexanalysis.ResultsInthreedifferentimmunestatus,allpatient
6、swithASandSSgroupsCD4Tcellpercentagesarelowerthannormalcontrolgroup(Pcontrolgroup>theASgroup(P7、ofCD4/CD8SSgroupweresignificantlylowerthantheASgrouporcontrolgroup,inastateofimmuneclearancetheSSandtheASgroupBlymphocytepercentagewerehigherthanthecontrolgroup.thepercentageofNKcellswaslowerthanthecontrolgroup(P<0.05).ConclusionChronicHBVinfectionhaveimmunedysfunction:HBVinfected8、differentimmunestatusofTCMclassif
7、ofCD4/CD8SSgroupweresignificantlylowerthantheASgrouporcontrolgroup,inastateofimmuneclearancetheSSandtheASgroupBlymphocytepercentagewerehigherthanthecontrolgroup.thepercentageofNKcellswaslowerthanthecontrolgroup(P<0.05).ConclusionChronicHBVinfectionhaveimmunedysfunction:HBVinfected
8、differentimmunestatusofTCMclassif
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