HGF的表达与口腔鳞癌VEGF-C表达及淋巴管生成关系的研究-论文.pdf

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1、口腔医学研究2014年3月第3O卷第3期245HGF的表达与口腔鳞癌VEGF-C表达及淋巴管生成关系的研究何等旗¨杜洪亮关泉林徐继莲张志瑞(1．兰州大学第一医院口腔颌面外科甘肃兰州730000；2．兰州大学第一医院肿瘤外科)[摘要]目的：探讨口腔鳞状细胞癌(OSCC)中肝细胞生长因子(HGF)的表达与血管内皮生长因子一C(VEGF-c)的表达及淋巴管生成的关系。方法：纳入经病理证实的7O例El腔鳞癌患者的手术切除标本，采用SP免疫组化技术检测HGF及VECF-C的表达情况并分析其与淋巴管密度(LVD)的关系，并结合临床病理参数作相关统计学分析。结果：淋巴结转移阳性病例的VE

2、GF—c表达明显升高(P一0．001)，VEGF—c的表达与其他病理参数无相关，另外，HGF的表达与临床病理参数无相关。VEGF—C高表达组的瘤周淋巴管密度(PLD)明显高于VEGF—c低表达组(P一0．001)，HGF表达及VEGF—c低表达组与瘤内及瘤周淋巴管的密度无相关性。另外，HGF的表达与VEGF-C的表达间无相关。结论：VEGF—C的表达与口腔鳞癌淋巴结转移密切相关，可能主要通过参与诱导口腔鳞癌淋巴管生成促进淋巴结转移。[关键词]肝细胞生长因子’血管内皮生长因子一C口腔鳞状细胞癌淋巴管生成[中图分类号]R739．8[文献标识码]A[文章编号]1671—7651(

3、2O14)O3一O245一O4RelationshipbetweenHGFExpressionandVEGF—CaswellasLymphangiogenesisinOralSquamousCellCarcinoma．HEDeng-qi，DUHong-liang，GUANQuan—lin，eta1．DepartmentofOralandMaxillofacialSurgery，TheFirstHospital，LanzhouUniversity，Lanzhou730000[-Abstract]Objective：Toexploretherelationshipbetween

4、hepatocytegrowthfactor(HGF)expressionandvascu—larendothelialgrowthfactorC(VEGF-C)aswellaslymphangiogenesisinoralsquamouscellcarcinoma(OSCC)．Methods：Seventyarchivalspecimensfrompatientswithoralsquamouscellcarcinomawereinvestigated，whoseclinicopathologicdatawerecompletelyconserved．Immunohist

5、ochemicalstainingwaspreformedtOdetecttheex—pressionofHGF。VEGF—Candlymphaticvesseldensity(LVD)．TherelationshipbetweenHGFandVEGF—C，lymphangiogenesis，aswellasotherclinic0pathologica1featuresweremeasured．Results：TherewerenocorrelationbetweenVEGF—Cexpressionandclinicopathologicdataexceptlymphno

6、demetastasis(P=0．001)．ThereWerenorelationshipbetweenHGFexpressionandclinicopathologicdata．Caseswithhigh—expressionofVEGF—Calsoshowedsignificantlymoreoftenhigherperitumorallymphaticdensity(PLD)．WhatSmore，therewerenocorrela—tionbetweenHGFexpressionandlymphaticvesselsdensity。butalsoHGFexpress

7、ionandVEGF—Cexpression．Conclusion：TheexpressionofVEGF—CiscloselyrelatedtOOSCC1ymphnodemetastasis．VEGF—cmaypro—motelymphnodemetastasisbyinducinglymphangiogenesisinOSCC．EKeywords]HepatocytegrowthfactorVascularendothelialgrowthfactorCOralsquamouscellcarcinoma(OS—