微波消融联合经脐静脉介入化疗治疗结肠癌肝转移瘤临床研究-论文.pdf

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1、右江医学2013年第41卷第5期YoujiangMedicalJournal2013，Vo1．41No5微波消融联合经脐静脉介人化疗治疗结肠癌肝转移瘤临床研究耀刘雷，黄世锋，张其顺‘，卢海明(广西医科大学第四附属医院肝胆外科，广西柳州545005)【摘要】目的探讨经皮微波消融(microwaveablation，MWA)联合经化疗泵脐静脉介人化疗治疗结肠癌肝转移瘤的临床价值。方法对83例结肠癌肝转移瘤行腔镜下结肠癌姑息性切除术后患者，按随机数字表法分为实验组(43例)和对照组(40例)，两组均在结肠癌姑息性切除的同时完成了经脐静脉插管皮下化疗泵埋置术，实验组行MwA+经化疗泵脐静脉介入化疗

2、。对照组单纯经化疗泵脐静脉介入化疗，治疗后进行随访。评价疗效和生存率。结果治疗后实验组CEA转阴率为76．4％，显著高于对照组的45．1(P0．05)。两组均无严重并发症。结论MWA联合经脐静脉介入化疗在结肠癌旰转移瘤的治疗中占有重要的位置，是一一种安全有效的治疗方法。K关键词】肝转移瘤；经皮微波消融术；介入化疗文章编号：1003—1383(2013)05⋯064304中图分类号：R735．35文献标识码：

3、Adoi：10．3969／j．issn．】003—1383．2013．05．003ClinicalstudyofmicrowaveablationcombiningumbilicalveininterVentiOnaIchemotherapytreatinghepaticmetastasisofcoloncancerLI[JLei，HUANGShng，ZHANGQishun，IUHaiming(DepartmentofG-eHera~Surgery，theFourthAfiliatedHospita￡()．厂GuangxiMedicalUniversity，Liuzhou545005，C^

4、ina)[Abstract]0bjeetiveToinvestigatethesignificanceofmicrowaveabtation(MWA)combiningumbilicalveininterventionalchemothelapy(UVIC)trearinghepaticmetastasispostlaparoscopicpalliativeresectionofcoloncancer．MethodsAtotalnumberof83caseswithhepaticmetastasispostlaparoscopicpalliativeresectionofcoloncanc

5、erwerecollectedandtheywererandomizedintoexperimentalgroup(=：43)andcontrolgroup(=40)withrandomdigitstable．BothgroupswereinsertedwithUVICpumpswhileundertakinglaparoscopicpalliativeresectionofcoloncancer．TheexperimentalgrouPreceivedUVIC+MWAandcontrolgroupreceivedsingleUVIC．Thepatientswerefollowedupan

6、dtheefficacyandsurvivalrateswereanalyzed．ResultsTherateofcarcino—embryonicantigen(CEA)becomingnegativeintheexperimentalgroupwashigherthanthatofthecontrolgroupwith76．4％against45．I％，(Pd0．05)．Thesurvivalrateswere88．3％，60．5％and38．2in1year，2yearand3year~．；intheexperimentala—gainst67．5，32．5and0．5intheco

7、ntrolgroup(P<0．05)．1’herewasnoseverecomplicationinbothgroups．ConclusionMWAcombiningUV1Cplaysimportantroleintreatinghepaticmetastasispostlaparoscopicpalliativere-sectionofcoloncancer，whichissafeandeffective．【Keywo