右美托咪定对七氟醚吸入麻醉妇科腹腔镜手术患者血浆胃动素及术后恶心呕吐的影响.pdf

《右美托咪定对七氟醚吸入麻醉妇科腹腔镜手术患者血浆胃动素及术后恶心呕吐的影响.pdf》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。

1、·论善·JMedRes，May2014，Vo1．43No．5右美托咪定对七氟醚吸入麻醉妇科腹腔镜手术患者血浆胃动素及术后恶心呕吐的影响王晓宁刘丽张丽红赵斌江摘要目的观察右美托咪定(DEX)对七氟醚吸人麻醉妇科腹腔镜手术患者血浆胃动素(MTL)及术后恶心呕吐(PONV)的影响。方法妇科腹腔镜手术患者50例，随机分为DEX组(D组)和对照组(c组)。D组予DEX1~g／kg并以0．2txg／(kg·h)维持，c组则予生理盐水。记录手术、吸人麻醉时间，七氟醚用量，苏醒和气管导管拔除时间；检测术前(T)、术后24h(T，)和术后48h(T)血浆MTL水平；随访PONV的发生情况。结果与c组比较，D组

2、七氟醚用量减少(P<0．05)，苏醒和气管导管拔除时间无明显延长(P>0．05)，T时点术后MTL水平显著降低(P<0．05)且术后24h内PONV发生率明显降低(P<0．05)。结论七氟醚吸人麻醉妇科腹腔镜手术应用DEX可减少七氟醚用量，不延长苏醒和气管导管拔除时间，减少MTL释放，显著降低PONV发生。关键词右美托咪定腹腔镜检查妇科外科手术胃动素手术后恶心呕吐[中图分类号]R614[文献标识码]AEfectsofDexmedetomidineonPlasmaMotilinLevelandPostoperativeNauseaandVomitinginPatientsUndergoingG

3、ynecologicalLaparo-scopicOperationunderSevofluraneInhalationAnesthesia．WangXiaoning，LiuLi，ZhangLihong，ZhaoBinjiang．DepartmentofAnesthesi—ology，BeqingShijitanHospitalAffiliatedtoCapitalMedicalUniversity，Beijing100038，ChinaAbstractObjectiveToobservetheefectsofdexmedetomidineonplasmamotilinlevelandpos

4、toperativenauseaandvomitinginpatientsundergoinggynecologicallaparoscopicoperation．MethodsInthisprospective，randomized，double—blindstudy，50ASAIandIIpatientsundergoingselectivelaparoscopicmyometomyundergeneralanesthesiawereincluded．Thepatientswererandomlyallocatedtotwogroups(n=25)：dexmedetomidinegrou

5、p(groupD)andcontrolgroup(groupC)．Dexmedetomidinewasgivenwith1~g／kgin20mlwithin10rainjustbeforeinductionofanesthesiaingroupD，andthesameVOIuITIeofnormalsalinewasgiveningroupCinthesameway．Thendexmedetomidinewasmaintainedat0．2g／(kg·h)until10minbeforetheendoftheoperationingroupD．Normalsa-linewasgivenatt

6、hesamemaintainspeedingroupC．Durationofoperationandanesthesia，consumptionofsevoflurane，emergencetime，extubationtimewererecorded，andthelevelofplasmmotilinwastestedatthreetimepoints：priortooperation(T0)，24hafteroperation(T1)and48hafteroperation(T2)，andtheoccurrenceofnauseaandvomitingwithin48hafteroper

7、ationwerealsorecorded．ResultsTheconsumptionofsevofluraneandtheoccurrenceofnauseaandvomitingwithin24hafteroperationingroupDweresignificantlylowerthanthoseingroupC(P<0．05)．Therewasnosignificantdiferenceinemer