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《右美托咪啶对高血压患者开颅术麻醉的影响.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、第50卷第8期山东大学学报(医学版)2012r8月Vo1.5ONo.8JOURNALOFSHANDONGUNIVERSITY(HEALTHSCIENCES)Aug.2012文章编号:1671—7554(2012)08—0081—03DOI:10.6040/j.issn.1671-7554.2012.08.017右美托咪啶对高血压患者开颅术麻醉的影响周廷发,唐贞申(1.临沂市人民医院麻醉科,山东临沂276000;2.山东大学附属省立医院麻醉科,济南250021)摘要:目的探讨右美托咪啶对高血压患者枕后开颅面神经显微血管减压术麻醉用药以及
2、麻醉苏醒的影响。方法选择合并高血压病面神经显微减压术患者48例,随机分为两组,每组24例。研究组麻醉诱导前静脉微量泵入右美托咪啶负荷量(1kg),继以维持0.2—0.7Ixg/(kg·h);对照组则微量泵入相同剂量的生理盐水。两组术中控制血压,收缩压维持在术前基础值的70%~80%。两组麻醉诱导选用丙泊酚、芬太尼和维库溴铵。以丙泊酚和瑞芬太尼持续泵注维持麻醉,观察两组患者麻醉药泵注速度、麻醉苏醒时间及拔管时间。结果研究组麻醉药泵注速度[丙泊酚(0.076±0.014)mg/(kg·min)vs(0.092±0.018)me:/(kg·
3、min);瑞芬太尼(0.106±0.032)(kg·min)vs(0.131±0.030)(kg·min)]、麻醉苏醒时间[(5.2±2.1)minvs(9.3±2.4)min]及拔管时间[(5.3±2.4)minvs(10.3±3.2)min]与对照组相比差异均有统计学意义(P均<0.05)。结论右关托咪啶用于高血压患者枕后开颅术可明显减少麻醉用药量,缩短麻醉苏醒时间,加快拔管。关键词:右美托咪定;高血压;面神经显微血管减压;开颅术;麻醉中图分类号:R614文献标志码:AEffectofdexmedetomidineongenera
4、lanesthesiainhypertensivepatientsundergoingcraniectomyZHOUTing.fa.TANGZhen.shen(1.DepartmentofAnesthesiology,LinyiPeoplesHospital,Linyi276000,Shandong,China;2.DepartmentofAnesthesiology,ProvincialHospitalAfiliatedtoShandongUniversity,Jinan250021,China)Abstract:Objective
5、Todetecttheeffectofdexmedetomidine(DEX)ongeneralanesthesiaofhypertensivepatientsundergoingretromastoidcraniectomyformicrovasculardecompression(MVD)offacialnerve.Methods48(ASAI一Ⅱ)hemifacialspasmpatientswithhypertensionundergoingretromastoidcraniectomyforMVDoffacialnerveu
6、ndergeneralanesthesiawererandomlydividedintotwogroups:thestudygroupandthecontrolgroup.Dexmedetomidinewasinjectedwiththeloaddosage(1kg)beforeanesthesia,followedbythemaintainingdosage[0.2-0.7(kg‘h)]duringanesthesiainthestudygroup.Sodiumchlorideinjectionwaspumpedinthecontr
7、olgroup.Anesthesiawasmain—tainedwithpropofolandremifentanil.Duringthesurgery,systolicbloodpressure(SBP)wasmaintained70%-80%ofthebaselinevaluebytitrationofanestheticdrugsand/ornitroglycerininbothgroups.Themeaninfusionratesofpropo—folandremifentanil,anesthesiarecoveryande
8、xtubationtimeswereobserved.ResultsComparedwiththecontrolgroup,patientsinthestudygrouprequiredlowernormalizedin
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