七氟烷吸入麻醉和丙泊酚全凭静脉麻醉对老年患者肝肾功能的影响.pdf

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1、中国现代医生2014年5月第52卷第15期·临床麻醉·七氟烷吸入麻醉和丙泊酚全凭静脉麻醉对老年患者肝肾功能的影响李红宝何建国1．宁波大学医学院附属医院麻醉科，浙江宁波315000；2．宁波市第一医院麻醉科，浙江宁波315010【摘要】目的比较七氟烷麻醉和丙泊酚麻醉对老年胃肠手术患者肝肾功能的影响。方法择期胃肠手术患者55例随机分为七氟烷麻醉组、丙泊酚麻醉组。监测术前和术后1d、3d患者血清天冬氨酸转移酶、丙氨酸转氨酶、血尿素氮和肌酸酐水平。结果与术前相比，两组患者AST术后1d、3d均升高，S组患者BUN在术后3d有升高，肌酸酐术后ld和3d均增加(P<0．05)。两组患者AI及T组患者BU

2、N和肌酸酐手术前后无显著变化(尸>0．05)。结论低剂量七氟烷吸入麻醉和丙泊酚静脉麻醉对老年患者肝肾功能的影响无显著差异。[关键词]吸入麻醉；全凭静脉麻醉；老年患者；肝肾功能【中图分类号】R614[文献标识码】B【文章编号]1673—9701(2014)15-0071-04Comparisonofhepaticandrenalfunctionbetweeninhalationanesthesiawithsevofluraneandtotalintravenousanesthesiawithpropofolforgeri—atricpatientsLIHongbaolHEjt叽1．Depart

3、mentofAnesthesiology，theAffiliatedHospitalofMedicalCollegeofNingboUniversity，Ningbo315000，Chi-na；2．DepartmentofAnesthesiology，NingboFirstHospital，Ningbo315010，China[Abstract]ObjectiveToinvestigatetheinfluenceofdifferentanesthesiamethodonhepaticandrenalfunctioninelderpatientsundergastrointestinalsur

4、gery．MethodsFifty—fivepatientswererandomlydividedintopropofolanesthesiagroupsandsevofluraneanesthesiagroups．Thehepaticandrenalfunction，aspartateaminotransferase(AST)，alanineaminotransferase(ALT)，bloodureanitrogen(BUN)andcreatinineweretestedatpreoperation(baseline)，postoper—ative1dayand3days．Results

5、ASTwasincreasedatpostoperative1dayand3days，comparedwiththatofthepreop-erationintheGroupSandGroupT．SerumBUNat3dayandcreatinineat1dayand3daysweresignificantlyhigherfromthepreoperativevaluesinGroupS(P<0．05)，butthevalueswerewithinitsnormallimit．ALTwasnotchangedaf-teranesthesiainthebothgroups．AndSerumBU

6、NandcreatininewerenotchangedafteranesthesiaintheTgroups(P>0．05)．TherewerenosignificantdifferencesintheALT，AST，BUNandcreatininebetweenthegroups(P>0．05)．Con·clusionTheseresultsshowthatthechangesofhepaticandrenaleffectafterinhalationanesthesiawithsevofluraneandremifentanilandTIVAwithpropofolandremifen

7、tanilforgastrointestinalsurgerywereclinicallyinsignficant，andtherewasnodifferencebetweenthetwomethods．[Keywords]Inhalationanesthesia；Totalintravenousanesthesia；Elderpatients；Hepaticandrenalfunction七氟烷吸入麻醉和丙