上海中医药大学-cloudfront.net.ppt

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1、LiuBaochiShanghaiPublicHealthClinicalCenteraffiliatedtoFudanUniversityTreatingpatientswithlivercirrhosisbyBMTDecompensatedlivercirrhosisisdifficulttocurelivercirrhosiswithAIDSismoredifficulttogiveeffectivetreatmentStemcelltreatmentbringthehopeforthepatientsofAIDSwithd

2、ecompensatedlivercirrhosis.BACKGROUND7AIDSpatientswithdecompensatedlivercirrhosisandportalvenhypertention,ascites,internalbloodingwereinvestigated.PatientsSplenectomywereperformedin7AIDSpatientswithlivercirrhosistoalleviateportalveinhypertentionandavoidinternalbloodin

3、g.MethodsDuringthesurgicalprocedure,acatheterwasplacedinthesuperiormesentericveininpreparationforbonemarrowtransfusion(BMT).20mLbonemarrowwasaspiratedbypunctureoftheiliaccrestoneweekaftersurgeryandtransfusedthroughtheattachedcatheterintotheportalvein.MethodsMethodsOne

4、ortwodosesofBMTwereperformedoneachpatientataonemonthinterval.ResultsExceptdiminishmentofascitesandrecoveryofserumalbuminlevels,totalwhitebloodcellsandplateletcountwasalsosignificantlyimproved.Unexpectedly,onemonthafterBMT,CD4+Tcellcountinperipheralbloodofall7patientsb

5、egantoincreasesignificantly.agebefore1month3month12month24month566181269341512368012036651954132274113026514124428923541199932661211127766361126353930349186476810871127agebefore1month3month12month24month56228318368512825365296216866487963227412563243123626494624181886

6、54247818929686391896353917468026982614862327changesofCD4+Tlymphcell(/ul)changesofCD8+Tlymphcell(/ul)agebefore1month3month12month24month5630.834.134.638.640.13633.535.636.838.838.932274127.436.331.338.236.828.637.938.634.238.139.638.238.841.135393734.139.438.436.339.2a

7、gebefore1month3month12month24month5612.913.616．416.115,23648.238.631.628.426.432274156.916.757.538.918.965.532.418.142.626.817.931.531.616.6353921.819.219.216.48.514.2changesofalbumin（g/L）changesofTbl（umol/L）agebefore1month3month12month24month552.16.65．45.16,2361.897.

8、66.66.45.43227412.1422.543.98.911.45.47.18.65.86.97.65.66.535393.355.555.15.47.46.4agebefore1month3month12month24month553630