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《原发性青光眼患者血清中维生素C、维生素E和尿酸水平的研究-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、国际检验医学杂志2014年1月第35卷第1期IntJLabMed,January2014,Vo1.35,No.1·19··临床检验研究论著·原发性青光眼患者血清中维生素C、维生素E和尿酸水平的研究赵雅,王睿,田英,田莹(1.西安市第一医院检验科,陕西西安710002:2.西安市第一医院眼科医院,陕西西安710002)摘要:目的探讨原发性青光眼(PG)患者及健康人血清中维生素C(VC)、维生素E(VE)及尿酸(uA)水平的差异。方法根据实验设计的纳入标准及剔除标准,选择42例PG患者作为研究对象,44例健康体检者
2、作为对照组。应用高效液相色谱法(HPIC)检测血清中Vc的浓度,应用可见分光光度法检测VE的浓度,应用比色法检测血清UA的浓度,应用SPSS17.0统计软件进行分析。结果PG组血清中VC浓度(3.63士1.45)/~g/mI,对照组为(5.54±1.64)/~g/mL,两组间差异有统计学意义(P<0.05);PG组血清VE浓度(4.97±0.88)/~g/mL,对照组为(6.48-+-1.17)tlg/mL,两组间差异有统计学意义(P3、38.45士74.72)/,mol/mI,对照组为(266.5O±81.5O)/lmol/mL,两组间差异无统计学意义(P>0.05);PG组男女之间血清Vc浓度差异无统计学意义(P>0.05),血清VE浓度差异无统计学意义(P>0.05);PG组不同年龄组之间血清VC浓度差异无统计学意义(P>0.05),血清VE浓度差异无统计学意义(P>0.05);PG组不同眼压组之间血清VC浓度差异有统计学意义(P0.05)。结论PG患者血清中VC、VE的浓度明显降低。关键词4、:青光眼;维生素类;尿酸;血清D0I:10.3969/j.issn.1673—4130.2O14.01.008文献标识码:A文章编号:l673—413O(2O14)01-0019一O4SerumvitaminC,vitaminEanduricacidlevelsinpatientswithprimaryglaucomaZhaoYa。WangRui,TianYing,TianYing(1.DepartmentofClinicalLaboratory,FirstHospitalofXian,Xian,Shaanxi5、710002,China;2.OphthalmologicHospital,FirstHospitalo/Xian,Xian,Shaanxi710002,China)Abstract:ObjectiveThepurposeofthispaperwastoevaluatethelevelsofvitaminC,vitaminEandUricAcid(UA)intheserumofpatientswithprimaiyglaucoma(PG).MethodsAccordingtotheinclusionandexc6、lusioncriteria,fortytwopatientswhosufferedfromPGwereselectedasstudyinggroupand44healthymenascontro1.SerumlevelsofvitaminC,vitaminEandUAweremeasuredusinghighperformanceliquidchromatography(HPLC),visiblespectrophotometryandcolorimetry,respectively.There—suitsw7、ereanalyzedstatisticallybySPSS17.0software.ResultsThemeanserumvitaminCconcentrationinPGgroup[(3.63±1.45)“g/mI]wassignificantlylowerthanthatincontrolgroup[(5.54士1.64)ptg/mL](P<0.05).ThemeanserumvitaminEconcentrationinPGgroup(4.97-+-0.88ug/mL)wassignificantlyl8、owerthanthatincontrolgroup[(6.48±1.17)t~g/mI](P<0.05).TherewasnosignificantdifferencebetweentheserumUAconcentrationofPGgroup[(238.45士74.72)/lmol/mL]andthecontrolgroup[(266.50士81.50)/~mol/mL](P>0
3、38.45士74.72)/,mol/mI,对照组为(266.5O±81.5O)/lmol/mL,两组间差异无统计学意义(P>0.05);PG组男女之间血清Vc浓度差异无统计学意义(P>0.05),血清VE浓度差异无统计学意义(P>0.05);PG组不同年龄组之间血清VC浓度差异无统计学意义(P>0.05),血清VE浓度差异无统计学意义(P>0.05);PG组不同眼压组之间血清VC浓度差异有统计学意义(P0.05)。结论PG患者血清中VC、VE的浓度明显降低。关键词
4、:青光眼;维生素类;尿酸;血清D0I:10.3969/j.issn.1673—4130.2O14.01.008文献标识码:A文章编号:l673—413O(2O14)01-0019一O4SerumvitaminC,vitaminEanduricacidlevelsinpatientswithprimaryglaucomaZhaoYa。WangRui,TianYing,TianYing(1.DepartmentofClinicalLaboratory,FirstHospitalofXian,Xian,Shaanxi
5、710002,China;2.OphthalmologicHospital,FirstHospitalo/Xian,Xian,Shaanxi710002,China)Abstract:ObjectiveThepurposeofthispaperwastoevaluatethelevelsofvitaminC,vitaminEandUricAcid(UA)intheserumofpatientswithprimaiyglaucoma(PG).MethodsAccordingtotheinclusionandexc
6、lusioncriteria,fortytwopatientswhosufferedfromPGwereselectedasstudyinggroupand44healthymenascontro1.SerumlevelsofvitaminC,vitaminEandUAweremeasuredusinghighperformanceliquidchromatography(HPLC),visiblespectrophotometryandcolorimetry,respectively.There—suitsw
7、ereanalyzedstatisticallybySPSS17.0software.ResultsThemeanserumvitaminCconcentrationinPGgroup[(3.63±1.45)“g/mI]wassignificantlylowerthanthatincontrolgroup[(5.54士1.64)ptg/mL](P<0.05).ThemeanserumvitaminEconcentrationinPGgroup(4.97-+-0.88ug/mL)wassignificantlyl
8、owerthanthatincontrolgroup[(6.48±1.17)t~g/mI](P<0.05).TherewasnosignificantdifferencebetweentheserumUAconcentrationofPGgroup[(238.45士74.72)/lmol/mL]andthecontrolgroup[(266.50士81.50)/~mol/mL](P>0
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