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时间:2020-04-25
《妊娠糖尿病患者血清同型半胱氨酸、胱抑素C、CRP水平的变化与意义-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、《中外医学研究》第12卷第2期(总第226期)2014~lfl医技与临床Yijiyulinchuang妊娠糖尿病患者血清同型半胱氨酸、胱抑素C、CRP水平的变化与意义冯尤健①张莹①【摘要1目的:探讨妊娠糖尿病(GDM)患者血清同型半胱氨酸(Hcy)、胱抑素C(CysC)、CRP水平的变化及其与胰岛功能的关系。方法:选择2012年1-12月笔者所在医院门诊确诊的240例GDM患者为观察组,100例同期健康孕妇作为对照组。通过对血Hey、CysC、CRP、空腹血糖fFBG)、空腹胰岛素(FINS)的测定,比较两组患者血Hcy、
2、CysC、CRP、FBG、FINS、HOMA—IR、HOMA—B水平,并分析血Hcv、CysC、CRP与HOMA—IR、HOMA-p的相关性。结果:观察组Hey、CysC、CRP、FBG、FINS、HOMA—IR水平高于对照组<0.05)。两组问HOMA—B比较,差异无统计学意义(尸>0.05)。Hcy、CysC、CRP与HOMA—IR正相关(PO.05)。结论:GDM患者HOMA—IR、FINS、CRP、Hcy、CysC明显升高,Hcy、CysC、CRP与HOMA—IR正相关。G
3、DM患者存在胰岛素抵抗及低度炎症反应,炎症因子与胰岛素抵抗密切相关,炎症因子参与了GDM的发生、发展,血Hey、CysC、CRP水平可作为GDM患者的监测指标。【关键词】妊娠期糖尿病;同型半胱氨酸;胱抑素C;C反应蛋白;胰岛功能中图分类号R714.25文献标识码A文章编号1674—6805(2014)2—0049—02TheChangesandSignificanceofHomocysteine,CystatinCandCRPLevelintheSerumofPatientswithGestationalDiabetesM
4、eilitus/FENGYou-jian,ZHANGYingJ/ChineseandForeignMedicalResearch,2014,12(2):49-50【Abstract】Objective:Toexplorethechangesofh0m0cysteine(Hcy),cystatinC(CysC)andCRPlevelintheserumofgestationaldiabetesmellituspatients(GDM),andtherelationshipbetweenthechangesofthatandi
5、sletfunction.Method:Atotalof240caseswithGDMdiagnosedbyoutpatientfromJanuarytoDecemberin2012wereselectedasanobservationgroup,and100healthypregnantwomeninthesameperiodasacontrolgroupwereselected.LevelsofHcy,CysC,CRP,FBG,FINS,HOMA-IRandHOMA-Binthebloodbetweenthesetwo
6、groupswerecomparedbydeterminingHcy,CysC,CRP,fastingbloodglucose(FBG)andfastinginsulin(FINS)intheblood.ThenthecorrelationbetweenHcy,CysC,CRPandHOMA-IR,HOMA~Bwereanalyzed.Result:ThelevelsofHcy,CysC,CRP,FBG,FINSandHOMA-IRintheobservationgroupweresignificantlyhigherth
7、anthatinthecontrolgroup(P0.05).ThelevelsofHcy,CysCandCRParepositivelycorrelatedwithHOMA—IR’slevel(P8、lsofHcy,CysCandCRP(尸>0.05).Conclusion:ThelevelsofHcy,CysC,CRP,FINSandHOMA—IRofGDMpatientsweresignificantlyincreased,andthelevelsofHcy,CysCandCRPareposit
8、lsofHcy,CysCandCRP(尸>0.05).Conclusion:ThelevelsofHcy,CysC,CRP,FINSandHOMA—IRofGDMpatientsweresignificantlyincreased,andthelevelsofHcy,CysCandCRPareposit
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