伽玛刀联合长春瑞滨、顺铂治疗局部晚期肺癌疗效观察-论文.pdf

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1、现代肿瘤医学2014年1月第22卷第1期MODERNONCOLOGY，Jan．2014，VOL．22，NO．01·81·伽玛刀联合长春瑞滨、顺铂治疗局部晚期肺癌疗效观察桑旭，朱婧妮，周后龙，韦淑贞，张闯TherapeuticeffectofbodygammaknifecombinedwithvinorelbineandDDPinpatientswithadvancedNSCLCSangXu，ZhuJingni，ZhouHoulong，WeiShuzhen，ZhangChuangBengbuMedicalCollegeG

2、raduateSchool，AnhuiBengbu233000，China；The82ndHospitalP，JiangsuHuai'an223001，China．【Abstract】Objective：Toexploretheclinicaleffectsandevaluatetoxicityofbodygammaknifecombinedwithvi—norelbineandDDP(NP)fortreatmentofadvancednon—smallcelllungcancer(NSCLC)．Methods：Tot

3、alof101patientswithNSCLCweredividedintotwogroupsrandomly：GroupA—bodygammaknifecombinedwithconcurrentchemotherapy(NP)(combinedtherapygroup)52cases；GroupB—chemotherapywithNPonly(controlgroup)49cases．Itwasdesignedtocomparetheshortterraeffect，survivaltime，andtoxicsi

4、deeffects．Results：TheeffectiveratesofgroupAandgroupBwere82．69％and53．06％．Oneyearsurvivalratesofthetwogroupswere69．23％and42．86％．Incombinedtherapygroupacuteradiationinducedlunginjurywas11．54％，acuteradiationinducedesoph—agusinjurywas9．62％，both1—2degree．Intwogroupshe

5、matologictoxicitymainlywasleukocytedecrease，alsonausea，vomiting，incombinedgroupobviouslyhigherthanthecontrolgroup．Butaftersymptomatictreatmentpatientscouldsuccessfullycompletedtreatment．Conclusion：BodygammaknifecombinedwithvinorelbineandDDPdramatic—allyincreaset

6、heshorttermeffectandsurvivaltimeofNSCLCpatients．Butleukocytedecrease，nausea，vomitingalso—increasedsignificantly．Somepatientshaveacuteradiationinducedlunginjuryandacuteradiationinducedesophagusinjury，buttheydontinfluencethetreatmentaftersymptomatictreatment．【Keyw

7、ords】bodygammaknjfe；conCurrentchem0therapy；non—smallzelllungcancer；sh0ntermtherapeuticeffec—tivenessModernOncology2014，22(01)：0081—0083【摘要】目的：探讨体部伽玛刀联合长春瑞滨、顺铂治疗局部晚期非小细胞肺癌的临床疗效及不良反应。方法：自2008年1月一2010年7月，对10l例非小细胞肺癌患者按治疗方法分为伽玛刀联合长春瑞滨、顺铂(联合组)52例和单纯应用长春瑞滨、顺铂(对照组)49例，

8、比较两组治疗后的近期疗效、生存期及不良反应。结果：联合组、对照组有效率分别为82．69％和53．06％，两组1年生存率分别为69．23％，42．86％。联合组的急性放射性肺损伤发生率11．54％，急性放射性食管损伤发生率9．62％，均为1—2度。两组的血液毒性主要表现为白细胞下降，另外还合并有恶心、呕吐等，联合组发生几率明显高于对