地佐辛超前镇痛对腹腔镜肝切除术患者血清IL-6、IL-10及术后疼痛的影响-论文.pdf

《地佐辛超前镇痛对腹腔镜肝切除术患者血清IL-6、IL-10及术后疼痛的影响-论文.pdf》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。

1、日固丽2014NO．21Medica1⋯药物与临床地佐辛超前镇痛对腹腔镜肝切除术患者血清IL-6、IL-10及术后疼痛的影响石世坚何忠承朱元嵩邢祖民佛山市顺德区第一人民医院麻醉科，广东佛山528300【摘要】目的评价地佐辛超前镇痛对腹腔镜肝切除患者术后疼痛及血清白介素6(I6)和白介素10(IL--10)-~达的影响。方法50例腹腔镜肝切除术患者，随机分为对照组与观察组，各25例。对照组：腹腔镜肝切除术患者未采取任何超前镇痛。观察组：腹腔镜肝切除术患者采用超前镇痛。结果观察组术后4、8、12、24h的患者VAS疼痛评分均低于对照组术后4、8、

2、12、24h的患者VAS疼痛评分，差异有统计学意义(P<0．01)。观察组术后4、8、12．24h的患者血清IL一6水平及血清IL-IO水平均低于对照组术后4、8、12、24h的患者血清IL．6水平及血清IL一1O水平，差异有统计学意义(尸<0．Ol一0．05)。结论腹腔镜肝切除术后患者采用地佐辛进行超前镇痛能有效减轻伤害后疼痛，而且能有效改善患者血清IL一6、IL一10水平，保持机体内部炎性因子与抗炎性因子浓度的平衡。化解术后患者体内的代谢紊乱，降低并发症的发生率。【关键词1地佐辛；超前镇痛；腹腔镜肝切除术；疼痛；白介素6；白介素10【中图

3、分类号】R6"14[文献标识码1A【文章编号11674—0742(2014)O7(c卜0086—03StudyontheEffectofDezocinePreemptiveAnalgesiaontheSerumIL一6，IL-10ExpressionandPostoperativePainofPatientswithLaparoscopicLiverResectionSHIShijianHEZhongchengZHUYuansongXINGZuminDepartmentofAnesthesiology，TheFimtPeople"sHospi

4、talofShunde，Foshan，GuangdongProvince，528300，China[Abstract]ObjectiveToevaluatetheefectofdezocinepreemptiveanalgesiaonthepostoperativepain，serumIL-6andIL-10expressionofpatientswithlaparoscopicliverresection．Methods50patientswithlaparoscopicliverresectionwererandomlydi-videdi

5、ntocontrolgroupandobservationgroup，25casesineach．Thecontrolgroup：thepatientsunderwentlaparoscopicliverre—sectionwerenotgivenanypreemptiveanalgesia．Theobservationgroup：thepatientsunderwentlaparoscopicliverresectionwereyenpreemptiveanalgesia．ResultsTheVASoftheobservationgroup

6、4h，8h，12h，24haftertheoperationwaslowerthanthatofthecontrolgroup，respectively，thedifferenceWasstatisticallysignificant(P<0．01)．ThelevelofselMmIL-6andIL-IOoftheob·servationgroup4h，8h，12h，24haftertheoperationwaslowerthanthatofthecontrolgroup，respectively，thediferenceWaSstatist

7、icallysignificant(P<0．O1~0．05)．ConclusionDezocinepreemptiveanalgesiaforpatientsafterlaparoscopicliverresectionvanefectivelyrelievethepainafterinjury，improvethelevelofserumIL一6andIL一10，maintainthebody"sinternalinflammatoryfac-torandanti-inflammatoryfactorconcentrationequilib

8、rium，dissolvethemetabolicdisorderinpatientsafteroperationandreducetheincidenceofco