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时间:2020-04-23
《曲马多与舒芬太尼术后镇痛对肿瘤手术切除患者NK细胞活力的影响-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、IlainanMedJ,Mar.2014,Vo1.25,No.6海南医学2014年3月第25卷第6期doi:10.3969/j.issn.1003—6350.2014.06.0323曲马多与舒芬太尼术后镇痛对肿瘤手术切除患者NK细胞活力的影响陈福春‘,张治明2方会龙‘,罗峰(1.湘南学院病原生物与免疫学教研室,湖南郴州423000;2.郴州市第一人民医院麻醉科,湖南郴州423000)【摘要】目的比较使用曲马多或舒芬太尼为肿瘤患者接受手术后实施术后镇痛治疗时对自然杀伤细胞fNK)活力的影响。方法4O例择期实施乳腺恶性肿瘤切除的患者随机分为两组各2O例,
2、分别接受曲马多1000mg(T组)或舒芬太尼100lag(S组)的术后镇痛治疗,在术后24h、48h进行镇痛的VAS评分。分别于术前,术后2h、12h、24h、48h抽取外周血液,测量NK细胞活力,并在两组之间进行比较。结果术后24h、48h,S组VAS均低于T组,其中第24小时,两组间差异有统计学意义(P<0.05);两组NK细胞活力在手术后均有下降,其中第2:J,n-,t下降最为明显,但两组间差异无统计学意义,术后第244',U1,"及48小时,两组间差异有统计学意义,T组恢复速度明显快于s组(尸<0.05)。结论衄马多镇痛效果较舒芬太尼稍差,但
3、其对NK细胞活力的抑制作用明显低于舒芬太尼。【关键词】术后镇痛;NK细胞;活力;曲马多;舒芬太尼【中图分类号】R730.56【文献标识码】A【文章编号】1003---6350(2014)06---0831—03EfectoftramadolorsufentanilonNKcellsactivitiesofcancerpatientsaftertumorsurgeryexc~ionaspatientcontroHedanalgesia.CHENFu—chun1.ZHANGZhi-ming2FANGHui-long1.LUOFengI.1.Departm
4、entofPathogensandImmunology,XiannanCollege,Chenzhou,42300~Hunan,CHINA;2.DepartmentofAnesthesiology,theFirstPeopleHospitalofChenzhou,Che~hou423000,Hunan,CHINA【Abstract】0bjectiveTocomparetheefectoftramadolorsufentanilinimmunesystemofbreastcan-cerpatientswhoreceivedtumorsurgeryexc
5、ision,whentheywereadministeredwithpatientscontrolledanalgesia(PCA).MethodsFortypatientsscheduledfortumorexcisionwereassignedtotwogroupsrandomly,groupTandgroupS,tobeadministeredwithtramadolorsufentanilasPCArespectively.VASdatawerecollectedat24hand48haftersurgery.Bloodsampleswere
6、collectedbeforesurgery,2h,12h,24hand48haftersurgeryfromperipheralveins.ResultsVASingroupSat24haftersurgeryweresignificantlylowerthanthatingroupTfP7、gactivityofNKcells,therecoveryspeedingroupTwassignificantlyhigherthanthatingroupS.ThereweresignificantdiferenceingroupTandgroupSat12h,24hand48hafterSur-gery.ConclusionTheefectsofPCAwithtramadolarenotasgoodassufentanilintumorexcisionofcancerpa-tients,butsuppressionsinNKcellsacti8、vitiesofTramadolaresignificantlylowerthanthatofSufenta
7、gactivityofNKcells,therecoveryspeedingroupTwassignificantlyhigherthanthatingroupS.ThereweresignificantdiferenceingroupTandgroupSat12h,24hand48hafterSur-gery.ConclusionTheefectsofPCAwithtramadolarenotasgoodassufentanilintumorexcisionofcancerpa-tients,butsuppressionsinNKcellsacti
8、vitiesofTramadolaresignificantlylowerthanthatofSufenta
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