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ID:36639090
大小:768.54 KB
页数:34页
时间:2019-05-13
《罗哌卡因复合曲马多与芬太尼术后硬膜外镇痛的临床研究》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、华中科技大学硕士学位论文罗哌卡因复合曲马多与芬太尼术后硬膜外镇痛的临床研究姓名:辛维政申请学位级别:硕士专业:麻醉学指导教师:姚尚龙2003.5.1华中辩技夫学嗣济医学陵硕{:学髓论文罗哌卡因复合曲马多与芬太尼术后硬膜外镇痛的l瓷床研究华中辩技大学嗣济医学院辫瘸滋强嚣院靡豁稀硕士研究生辛维政导筛姚尚龙教授摘要目的芬太尼配伍罗哌卡因用于术后硬膜外镇痛可以减少罗哌卡因的厢量,避免高浓瘦罗碾卡因对运动神经的阻滞,怒临床上常用的配伍方法之一。但芬太尼可导致较高的恶心、呕吐、皮肤瘙痒发生率,且有严重呼吸抑制的顾虑。肋马多是一种非麻醉性中枢镇痛药,同强效麻醉性镇痛药甥魄具确‘裂侔用小
2、,极少有呼吸麴刽发生的特点。匿此比较基马多、芬太尼分别和罗哌卡因合用对于术后硬膜外镇痛的作用,以期为临床安全合理怒药提{茭依据。方法选择ASAf~If级经腹子宫垒切患者60例,随机分为三组。R组:0.i5%罗鞭卡西3、。镇薅结寒嚣,由病久及蒸家属遴行总钵满意菠评分。所得各项结果进行统计学分析。华中科技人学同济医学院硕士学位论文果F组和T组VAS评分无明显差异(P>O.05),R组VAS评分明显组以及T组,有显著差异(P4、结论曲马多、芬太尼分别与罗哌卡因合用可以达到有效的术后硬膜外镇痛5、效果。但曲马多与罗哌卡因复合较芬太尼与罗哌卡因复合应用恶心、呕吐、皮肤瘙痒副作用低,较易被病人接受,且无呼吸抑制等严重副作用的顾虑,是一种较为安全有效的硬膜外术后镇痛配方。关键词罗哌卡因:曲马多;芬太尼;硬膜外;术后镇痛2坐生型垫盔堂旦堕堕堂堕!塾堂鱼堕!!一AcomparisonofepiduralropivacaineinfusioncombinedwithfentanylortramadolforpostoperativeanalgesiaafterabdominalhysterectomyDepartmentofAnesthesiology,UnionHospit6、al,TongjiMedicalCollege,HuaZhongUniversityofScienceandTechnologyPostgraduate:XinWeizhengTutor:Prof.YaoShanglongAbstractObjective:Theinfusionofropivacainecombinedwithfentanyliscommonlyappliedtocontinuousepiduralpostoperativeanalgesia.Fentanylresultsinlowerrequirementofropivacaine(volumeand7、concentration),butthehigherincidenceofnauseaandvomiting.Tramadolisallatypicalopioid.Itresultsinlowerincidenceofnauseaandvomitingincomparisonwithpotentopioids.Tocomparetheeff'ectofequivalentdoseoffemanylandtramadolincombinationwithropivacaineoncontinuousepiduralpostoperativeanalgesiaaftera8、bdominalhysterectomyisofsignificanceforsafetyandreasonableadministrationinepiduralpostoperativeanalgesia.Methods:Sixtypatientsundergoingabdominalhysterectomy,ASAclassI~II.wererandomlydividedintothreegroups—GroupR:0.15%ropivacaineinfusionalone(n_20);GroupF:O.15%ropiv
3、。镇薅结寒嚣,由病久及蒸家属遴行总钵满意菠评分。所得各项结果进行统计学分析。华中科技人学同济医学院硕士学位论文果F组和T组VAS评分无明显差异(P>O.05),R组VAS评分明显组以及T组,有显著差异(P4、结论曲马多、芬太尼分别与罗哌卡因合用可以达到有效的术后硬膜外镇痛5、效果。但曲马多与罗哌卡因复合较芬太尼与罗哌卡因复合应用恶心、呕吐、皮肤瘙痒副作用低,较易被病人接受,且无呼吸抑制等严重副作用的顾虑,是一种较为安全有效的硬膜外术后镇痛配方。关键词罗哌卡因:曲马多;芬太尼;硬膜外;术后镇痛2坐生型垫盔堂旦堕堕堂堕!塾堂鱼堕!!一AcomparisonofepiduralropivacaineinfusioncombinedwithfentanylortramadolforpostoperativeanalgesiaafterabdominalhysterectomyDepartmentofAnesthesiology,UnionHospit6、al,TongjiMedicalCollege,HuaZhongUniversityofScienceandTechnologyPostgraduate:XinWeizhengTutor:Prof.YaoShanglongAbstractObjective:Theinfusionofropivacainecombinedwithfentanyliscommonlyappliedtocontinuousepiduralpostoperativeanalgesia.Fentanylresultsinlowerrequirementofropivacaine(volumeand7、concentration),butthehigherincidenceofnauseaandvomiting.Tramadolisallatypicalopioid.Itresultsinlowerincidenceofnauseaandvomitingincomparisonwithpotentopioids.Tocomparetheeff'ectofequivalentdoseoffemanylandtramadolincombinationwithropivacaineoncontinuousepiduralpostoperativeanalgesiaaftera8、bdominalhysterectomyisofsignificanceforsafetyandreasonableadministrationinepiduralpostoperativeanalgesia.Methods:Sixtypatientsundergoingabdominalhysterectomy,ASAclassI~II.wererandomlydividedintothreegroups—GroupR:0.15%ropivacaineinfusionalone(n_20);GroupF:O.15%ropiv
4、结论曲马多、芬太尼分别与罗哌卡因合用可以达到有效的术后硬膜外镇痛
5、效果。但曲马多与罗哌卡因复合较芬太尼与罗哌卡因复合应用恶心、呕吐、皮肤瘙痒副作用低,较易被病人接受,且无呼吸抑制等严重副作用的顾虑,是一种较为安全有效的硬膜外术后镇痛配方。关键词罗哌卡因:曲马多;芬太尼;硬膜外;术后镇痛2坐生型垫盔堂旦堕堕堂堕!塾堂鱼堕!!一AcomparisonofepiduralropivacaineinfusioncombinedwithfentanylortramadolforpostoperativeanalgesiaafterabdominalhysterectomyDepartmentofAnesthesiology,UnionHospit
6、al,TongjiMedicalCollege,HuaZhongUniversityofScienceandTechnologyPostgraduate:XinWeizhengTutor:Prof.YaoShanglongAbstractObjective:Theinfusionofropivacainecombinedwithfentanyliscommonlyappliedtocontinuousepiduralpostoperativeanalgesia.Fentanylresultsinlowerrequirementofropivacaine(volumeand
7、concentration),butthehigherincidenceofnauseaandvomiting.Tramadolisallatypicalopioid.Itresultsinlowerincidenceofnauseaandvomitingincomparisonwithpotentopioids.Tocomparetheeff'ectofequivalentdoseoffemanylandtramadolincombinationwithropivacaineoncontinuousepiduralpostoperativeanalgesiaaftera
8、bdominalhysterectomyisofsignificanceforsafetyandreasonableadministrationinepiduralpostoperativeanalgesia.Methods:Sixtypatientsundergoingabdominalhysterectomy,ASAclassI~II.wererandomlydividedintothreegroups—GroupR:0.15%ropivacaineinfusionalone(n_20);GroupF:O.15%ropiv
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