^188Re标记叶酸偶联白蛋白纳米微球对SKOV3人卵巢癌生长抑制作用研究-论文.pdf

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1、978TianiinMedJ，Oct2013，Vol41Nol0实验研究doi：10．3969~．issn．0253—9896．2013．10．010Re标记叶酸偶联白蛋白纳米微球对SKOV人卵巢癌生长抑制作用研究唐秋莎陈道桢臧嘉郭彩琴【摘要】目的观察核素标记叶酸靶向白蛋白纳米微球(Re—folate-CDDP／HASMNP)~SKOV，人卯巢癌细胞生长作用的影响。方法建立人卵巢癌细胞SKOV裸鼠模型，并将64只荷瘤鼠随机分成8组，每组8只，分别为(A)阴性对照组；(B)采用CDDP方案化疗的单纯化疗组；(C)核素靶向内照射的单纯放疗组；(

2、D)磁感应热疗的单纯热疗组；(E)化疗联合放疗组；(F)化疗联合热疗治疗组；(Gj放疗联合热疗治疗组；(H)热疗、化疗、放疗联合治疗组。各组经治疗后，观察肿瘤生长增殖情况，计算肿瘤质量抑制率，观察肿瘤组织病理变化。结果各治疗组的肿瘤质量均低于对照组(P<0．05)，且与其他治疗组相比，热疗、化疗、放疗联合治疗组的肿瘤质量最低(P<0．05)。结论磁感应热疗、化疗、核素靶向内照射放疗的联合作用能有效抑制卵巢癌的生长，对卵巢癌治疗具有潜在应用前景。【关键词】顺铂；叶酸；纳米粒子；白蛋白类；卵巢肿瘤；癌；放射疗法；透热疗法；抗肿瘤联合化疗方案Th

3、eInhibitoryEffectsof’舳Re—LabeledFolateCouplingwithMagneticAlbuminNanoparticlesonSKOV3OvarianCancerinVivoTANGQiusha，CHENDaozhen，ZANGJia，GUOCaiqinDepartmentofPathologyandPathophysiology,BasicSchoolofMedicalScience，SoutheastUniversity，Nanjing210009，China；2CentralLaboratory,Th

4、eAffiliatedMaternalandChildHealthCareHospitalofNanfingMedicalUniversity【Abstract】0bjectiveToinvestigatetheeffectsofisotopelabeledfolatetargetingalbuminnanopartieles(Re—fo—late—CDDP／HASMNP)onhumanSKOV3ovariancancercellsinvivo．MethodsThehumanSKOV3ovariancancermodelwasestabli

5、shedinmice．Sixty—fourtumor—bearingmicewererandomlydividedintoeightgroups：(A)negativecontrolgroup，(B)chemotherapygroup，(C)radiotherapyalonegroup，(D)hyperthermiaalonegroup，(E)chemotherapycombinedwithradio—therapygroup，(F)chemotherapycombinedwithhyperthermiatherapygroup，(G)ra

6、diotherapycombinedwithhyperthermiatherapygroupand(H)hyperthermia，chemotherapyandradiotherapycombinedtreatmentgroup．Aftertreatment，thecellpro—liferationandtumorgrowthwereobserved．Theinhibitoryrateoftumormasswasmeasured．Thehist0pathologicalchangesoftumorwereobservedinallgrou

7、ps．ResultsThequalityoftumorwassignificantlylowerintreatmentgroupsthanthatofcontrolgroupfP<0．05)．Therewasthelowestqualityoftumorinhyperthermia．chemotherapyandradiotherapycombinedtreatmentgroupthanthatofothertreatmentgroupsfP<0．05)．ConclusionThecombinationofmagneticinduction

8、hyper—thermia，chemotherapy，targetedradionuclideofradiationexposurecaneffectivelyinhibitth