子宫颈癌放疗同步化疗治疗中顺铂用药临床观察.pdf

《子宫颈癌放疗同步化疗治疗中顺铂用药临床观察.pdf》由会员上传分享，免费在线阅读，更多相关内容在应用文档-天天文库。

1、中闽医科大学学报第42卷第l2期2013年12月JournalofChinaMedicalUniversityVo1．42No．12Dec．2013·1087··论著·子宫颈癌放疗同步化疗治疗中顺铂用药临床观察张文陆，王言，崔慧霞(辽宁医学院1．附属第一医院综合八病区，2．护理学院，辽宁锦州121001)摘要目的观察放疗与顺铂同步化疗治疗子宫颈鳞癌中，顺铂用药周期数、用药剂量、近期疗效和不良反应。方法回顾分析51例Ibl～IIIb期子宫颈鳞癌患者，行盆腔野放疗(剂量45～50Gy／5周)，同时应用顺铂每周方案(顺铂30mg／m，每周1次，静脉滴注)进行化疗，35例Ibl～

2、lIb子宫颈鳞癌单纯放疗，观察其近期疗效和不良反应，记录放化同步治疗组患者应用顺铂的周期数及顺铂剂量。结果应用DDP30mg／m每周1次放疗化疗同步治疗的中位化疗周期为4周，与单纯放疗组相比，放化同步治疗患者的白细胞计数显著低于放疗组，恶心呕吐的发生率显著高于放疗组，差异具有统计学意义(P

3、癌治疗有着较好的临床疗效。关键词子宫颈癌；顺铂；放化同步治疗中图分类号R737．3文献标志码A文章编号0258—4646(2013)12—1087—04网络出版地址http：／／www．enki．net／kcms／detail／21．1227．R．20131230．1053．008．htmlClinicalObservationofCisplatininCervicalCancerRadiotherapySynchronousChemotherapyZHANGWen．1u，WANGYan，CUIHui—xi~(1．TheFirstAfiliatedHospitalofLi

4、aoningMeScalColege，Jinzhou121001，China；2．NursingSchoolofLiaoningMedicalCollege，Jinzhou121001，China)AbstractObjectiveToobservethenumberofcyclesofcisplafinmedication，medicationdose，efficacyandadversereactionsintheehemothera—PYofcervicalcancerradiotherapysynchronous．MethodsAretrospectiveanal

5、ysiswasperformed，including51easesofIbltotheSbphaseeer—vicalcancerpatientswithpelvicfieldradiotherapy(doseof45to50Gy／5weeks)，synchronouschemotherapy，weeklycisplatin(cisplatin30mg／m2weeklyintravenousinfusion)treatment，andanother35casesofIbltombcervicalcancerwithradiothempyonly．Theeficacyand

6、adve~ere—actionswererecorded．ResultsDDPWasadministratedatadoseof30mg／m2onceaweekinthecervicalcancerradiotherapysynchronousehemo—therapy，themediancycleofchemotherapyisfourweeks，thepatientSleukocyteeoun~ofradiotherapysynchronouschemotherapygroupweresig—nificanflylowerthantheradiotherapygrou

7、p，theincidenceofnauseaandvomitingwassignificantlyhigherintheradiotherapysynchronouschemo—therapygroup，thediferenceswerestatisticallysignificant(P<0．05)．However，inthelong—termeficacy，radiotherapysynchronouschemotherapyshoweda3-yeardisease—freesurvivalrateof92．7％．5-ye