替吉奥联合多西他赛和顺铂治疗进展期胃癌的临床观察.pdf

《替吉奥联合多西他赛和顺铂治疗进展期胃癌的临床观察.pdf》由会员上传分享，免费在线阅读，更多相关内容在应用文档-天天文库。

1、·l58·实用癌症杂志2013年3月第28卷第2期ThePracticalJournalofCancer，March2013，Vol28，No．2替吉奥联合多西他赛和顺铂治疗进展期胃癌的临床观察邱国钦许丽贞林智才陈玉强崔殿龙【摘要】目的观察替吉奥联合多西他赛和顺铂(DCS方案)一线治疗进展期胃癌的有效性及安全性。方法采用随机、对照、开放性的临床试验设计。入选96例初治的进展期胃癌患者，随机分为2组，治疗组48例采用DCS方案化疗：对照组48例．采用多西他赛、顺铂、亚叶酸钙及氟尿嘧啶方案(DCF方案)化疗；至少化疗3个周期后评价疗效及不良反应。

2、结果治疗组的近期有效率(RR)为83．3％，优于对照组的54．2％，差异有统计学意义(P<0．05)；治疗组中位rrP和MST分别为7．5个月和12．1个月，均高于对照组的5．6个月和8．4个月；治疗组的不良反应及严重反应发生率均明显低于对照组(P<0．05)。结论替吉奥联合多西他赛和顺铂化疗方案一线治疗进展期胃癌疗效确切，不良反应较少，患者耐受性良好。【关键词】进展期胃癌；化学治疗；替吉奥；多西他赛；顺铂DOI：10．3969／j．issn．1001—5930．2013．02．015中图分类号：R735．2文献标识码：A文章编号：1001-

3、5930(2013)02-0158-03ClinicalObservationofS．1CombinedwithDocetaxelandCisplatinintheTreatmentofPatientswithAdvancedGastricCarcinomaQIUGuo—qin，XULi—zhen，L1NZhi—cai，eta1．DepartmetofOncology，ChenggongHospitalAffiliatedtoXiamenUniversity，the174HospitalofPeople&LiberationArmy，Xiam

4、en，361003【Abstract】ObjectiveToevaluatetheeficacyandsafetyofthecombinationofS-1withDocetaxelandCisplatin(DCStherapeuticregimens)asafirstlineregimeninthetreatmentofpatientswithadvancedgastriccarcinoma．MethodsArandom—ized，control，openclinicaltrialwasdesigned，96patientswithadva

5、ncedgastriccarcinomawererandomlydividedintotwogroups．Theexperimentalgroup(48patients)wastreatedbyusingtheDCStherapeuticschedules；thecontrolgroupwastreatedbyDoxt—axol，Cisplatin，CalciumFolinateand5-FU(DCFtherapeuticregimens)．Theshort—termeficacyandadversereactionswereeval—uat

6、edafteratleastthreetreatmentcycles．ResultsAllthe96patientsweresuitableforevaluation．Thetumorresponserate(RR)oftheexperimentalgroupwasbetterthanthatofthecontrolgroup(83．3％VS．54．2％，P<0．05)．Besides，themediantimetoprogression(MTI'P)andmediansurvivaltime(MST)were7．5monthsand12．1

7、monthsintheexperimentalgroup，whichwerelongerthanthatofthecontrolgroup(5．6and8．4months，respectively)．Inaddition，comparedwiththecontrolgroup．occurrencerateofadversereactionsandseriousresponseoftheexperimentalgroupweresignificantlylower(P<0．05)．ConclusionTheDCStherapeuticregim

8、enshoweddefinitecurativeeffectinthetreatmentofpatientswithadvancedgastricear—cinom