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时间:2017-12-08
《用pdca循环管理社区健康服务中心医院感染控制质量调查》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、万方数据些有希望的小分子化合物。由于小分子抑制剂在合成的容易、mTOR抑制剂的研究将会日益活跃。稳定性甚至活性等方面比雷帕霉素更优越,所以对小分子[1][2][3][4][5][6][7】[8][9]【10】圈3椰衄a加in(5)圈4DKBSG557(7)参考文献张世良,王立东.肿瘤分子细胞遗传学.郑州大学出版社.2002.金惠铭,卢建.殷莲华.细胞分子病理生理学.郑州大学出版杜.2002.李民。赵明.雷帕霉素的作用机制和临床应用田.国外医学药学分,2002,29(3):5.162.MitBMM,Mira人R
2、ewinskyEK.Mammalientargetofmpamycin:AnewmoleculartatSetforbreastcBn孵Clin.BmastC矗no旺2003,4(2):37·126.Huang&andH∞蛔PJ.Inllibitoll$0fmammatiantargd0fnt-pemycin.novelanfitunmragents:FrombenchtOclinic.Cue.OphInvest.Dm乒2002,3:295-304.NelsonFC,StachelSJ,etc.Manipul
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6、ed.Chem.2002,10:167-174.[12]ⅥBh∞CJ,MatterWF,HuiKYandBwmRF.Aspecificinhib-itOrofphoephatidyIinmitol3-kinase。2-(4-morpholinyl)-8-phenyl-III-1-benzopyran一、ne(LY294002).Bi01.Chem.1994,269(7):48-5241.[13]GriR"mRJ,FontanaG,GoldingBT.SelectiveBenmpyranoneandpyrimi
7、do[2,l-a]isoquinolin-4-oneinhibitonofDNA-depond-entproteinkinase:synthesis,sUucUlre·activitystudies,andradi—osensit6AfionofaHimpnTl哪CellLineinvitro..Me&Chem.2005。48(2):85-569.[14】KdstofAS,Pacheco-Roddgu%G,SchmmmerB,MoosJ.LY303511(2-pipemzinyl-8一phenyl.4H·1-
8、benmpyran-4-one)actsviaphc目phafidyfinositol3-kimme·independentpathways协inhibitcelIproliferationviam曲m幽tEsetofrapamyein(roTOR)-andnon—mTOR-dependentmecha·血nPbaramcoLEzp.Ther.2005.314(3):43·1134.[15]ReddyMA,PramdaraoNV,Wmc^-Phosphatidylin∞i·tol3-Kinaseactivat
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